Design of an L-Valine-Modified Nanomicelle-Based Drug Delivery System for Overcoming Ocular Surface Barriers

Design of an L-Valine-Modified Nanomicelle-Based Drug Delivery System for Overcoming Ocular Surface Barriers

The incidence of ocular surface disease (OSD) is increasing, with a trend towards younger ages. However, it is difficult for drugs to reach the deep layers of the cornea due to ocular surface barriers, and bioavailability is less than 5%. In this study, DSPE-PEG2000 was modified with L-valine (L-Val...

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Bibliographic Details
Main Authors: Huimin Wu, Yuchen Xu, Mengru Cai, Longtai You, Jing Liu, Xiaoxv Dong, Xingbin Yin, Jian Ni, Changhai Qu
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Pharmaceutics
Subjects:
L-valine
nanomicelles
baicalin
PepT1
endocytosis proteins
tight junction proteins
Online Access:https://www.mdpi.com/1999-4923/14/6/1277

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