Molecular modelling of fentanyl analogs
Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relation...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2004-01-01
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| Series: | Journal of the Serbian Chemical Society |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390411843D.pdf |
| _version_ | 1818877879030644736 |
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| author | Došen-Mićović Ljiljana I. |
| author_facet | Došen-Mićović Ljiljana I. |
| author_sort | Došen-Mićović Ljiljana I. |
| collection | DOAJ |
| description | Fentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper. |
| first_indexed | 2024-12-19T14:05:17Z |
| format | Article |
| id | doaj.art-41334874c9d448efbea252bd6ff21eae |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-19T14:05:17Z |
| publishDate | 2004-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-41334874c9d448efbea252bd6ff21eae2022-12-21T20:18:20ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212004-01-01691184385410.2298/JSC0411843D0352-51390411843DMolecular modelling of fentanyl analogsDošen-Mićović Ljiljana I.0Faculty of Chemistry, Belgrade and Center for Chemistry, ICTM, Belgrade, Serbia and MontenegroFentanyl is a highly potent and clinically widely used narcotic analgesic. A large number of its analogs have been synthesized, some of which (sufentanil and alfentanyl) are also in clinical use. Theoretical studies, in recent years, afforded a better understanding of the structure-activity relationships of this class of opiates and allowed insight into the molecular mechanism of the interactions of fentanyl analogs with their receptors. An overview of the current computational techniques for modeling fentanyl analogs, their receptors and ligand-receptor interactions is presented in this paper.http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390411843D.pdffentanyl analogsmolecular modelingμ-receptorligand-receptor interactions |
| spellingShingle | Došen-Mićović Ljiljana I. Molecular modelling of fentanyl analogs Journal of the Serbian Chemical Society fentanyl analogs molecular modeling μ-receptor ligand-receptor interactions |
| title | Molecular modelling of fentanyl analogs |
| title_full | Molecular modelling of fentanyl analogs |
| title_fullStr | Molecular modelling of fentanyl analogs |
| title_full_unstemmed | Molecular modelling of fentanyl analogs |
| title_short | Molecular modelling of fentanyl analogs |
| title_sort | molecular modelling of fentanyl analogs |
| topic | fentanyl analogs molecular modeling μ-receptor ligand-receptor interactions |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2004/0352-51390411843D.pdf |
| work_keys_str_mv | AT dosenmicovicljiljanai molecularmodellingoffentanylanalogs |