Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime
The intermittent fasting regimen (IFR) has been certified as an effective strategy for improving metabolism. But the underlying mechanism is still obscure. Beige induction in white adipose tissue (WAT) by IFR may account for this. It has been demonstrated that the erupting of pregnancy zone protein...
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| Format: | Article |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.950619/full |
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| author | Xiaoxiao Jiang Xiaoxiao Jiang Xiaoxiao Jiang Jun Lin Meng Dong Xiaomeng Liu Yuanyuan Huang Hanlin Zhang Hanlin Zhang Rongcai Ye Rongcai Ye Huiqiao Zhou Huiqiao Zhou Chunlong Yan Shouli Yuan Li Chen Li Chen Rui Jiang Rui Jiang Kexin Zheng Wanzhu Jin Wanzhu Jin |
| author_facet | Xiaoxiao Jiang Xiaoxiao Jiang Xiaoxiao Jiang Jun Lin Meng Dong Xiaomeng Liu Yuanyuan Huang Hanlin Zhang Hanlin Zhang Rongcai Ye Rongcai Ye Huiqiao Zhou Huiqiao Zhou Chunlong Yan Shouli Yuan Li Chen Li Chen Rui Jiang Rui Jiang Kexin Zheng Wanzhu Jin Wanzhu Jin |
| author_sort | Xiaoxiao Jiang |
| collection | DOAJ |
| description | The intermittent fasting regimen (IFR) has been certified as an effective strategy for improving metabolism. But the underlying mechanism is still obscure. Beige induction in white adipose tissue (WAT) by IFR may account for this. It has been demonstrated that the erupting of pregnancy zone protein (PZP) from the liver coincides with membrane translocation of grp78 in brown adipocytes during IFR to activate brown adipose tissue (BAT), which may partly explain the metabolic benefits of IFR. Liver-derived PZP appears to be responsible for all metabolic regulatory functions; the effect of boosting energy expenditure disappeared in liver-deficient mice. To verify whether any liver-specific modification was essential for functional PZP, we used the PZP adipose tissue-specific overexpression mice model (PZP TG). We found that the metabolic disorders induced by high-fat diet were improved in PZP TG mice under IFR. Additionally, in addition to the activation of BAT, UCP1 protein and angiogenesis were increased in WAT, as well as the expression of genes associated with glucose utilization. These results demonstrate that PZP fat-specific TG increased the energy conversion of WAT, indicating that WAT may be another direct target for PZP during IFR. |
| first_indexed | 2024-04-12T06:20:14Z |
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| id | doaj.art-41341786da0b4d57abfcdab8c33cf7b4 |
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| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T06:20:14Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Physiology |
| spelling | doaj.art-41341786da0b4d57abfcdab8c33cf7b42022-12-22T03:44:21ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-08-011310.3389/fphys.2022.950619950619Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting RegimeXiaoxiao Jiang0Xiaoxiao Jiang1Xiaoxiao Jiang2Jun Lin3Meng Dong4Xiaomeng Liu5Yuanyuan Huang6Hanlin Zhang7Hanlin Zhang8Rongcai Ye9Rongcai Ye10Huiqiao Zhou11Huiqiao Zhou12Chunlong Yan13Shouli Yuan14Li Chen15Li Chen16Rui Jiang17Rui Jiang18Kexin Zheng19Wanzhu Jin20Wanzhu Jin21Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaGuangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaInstitute of Neuroscience and Translational Medicine, College of Life Science and Agronomy, Zhoukou Normal University, Zhoukou, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaAgriculture College of Yanbian University, Yanji, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaInstitute of Infectious Disease, Ditan Hospital, Capital Medical University, Beijing, ChinaKey Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, ChinaUniversity of Chinese Academy of Sciences, Beijing, ChinaThe intermittent fasting regimen (IFR) has been certified as an effective strategy for improving metabolism. But the underlying mechanism is still obscure. Beige induction in white adipose tissue (WAT) by IFR may account for this. It has been demonstrated that the erupting of pregnancy zone protein (PZP) from the liver coincides with membrane translocation of grp78 in brown adipocytes during IFR to activate brown adipose tissue (BAT), which may partly explain the metabolic benefits of IFR. Liver-derived PZP appears to be responsible for all metabolic regulatory functions; the effect of boosting energy expenditure disappeared in liver-deficient mice. To verify whether any liver-specific modification was essential for functional PZP, we used the PZP adipose tissue-specific overexpression mice model (PZP TG). We found that the metabolic disorders induced by high-fat diet were improved in PZP TG mice under IFR. Additionally, in addition to the activation of BAT, UCP1 protein and angiogenesis were increased in WAT, as well as the expression of genes associated with glucose utilization. These results demonstrate that PZP fat-specific TG increased the energy conversion of WAT, indicating that WAT may be another direct target for PZP during IFR.https://www.frontiersin.org/articles/10.3389/fphys.2022.950619/fullintermittent fasting regimenpregnancy zone proteinwhite adipose tissuebeigevascularization |
| spellingShingle | Xiaoxiao Jiang Xiaoxiao Jiang Xiaoxiao Jiang Jun Lin Meng Dong Xiaomeng Liu Yuanyuan Huang Hanlin Zhang Hanlin Zhang Rongcai Ye Rongcai Ye Huiqiao Zhou Huiqiao Zhou Chunlong Yan Shouli Yuan Li Chen Li Chen Rui Jiang Rui Jiang Kexin Zheng Wanzhu Jin Wanzhu Jin Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime Frontiers in Physiology intermittent fasting regimen pregnancy zone protein white adipose tissue beige vascularization |
| title | Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime |
| title_full | Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime |
| title_fullStr | Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime |
| title_full_unstemmed | Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime |
| title_short | Overexpression of Pregnancy Zone Protein in Fat Antagonizes Diet-Induced Obesity Under an Intermittent Fasting Regime |
| title_sort | overexpression of pregnancy zone protein in fat antagonizes diet induced obesity under an intermittent fasting regime |
| topic | intermittent fasting regimen pregnancy zone protein white adipose tissue beige vascularization |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.950619/full |
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