Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation
Abstract Most treatment planning systems of boron neutron capture therapy perform dose calculations based on the assumption of a homogeneous boron distribution in tumors, which leads to dose distortion due to the difference between the tumor-to-normal tissue ratio (TNR) range measured in positron em...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-09-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-42284-x |
| _version_ | 1797453125477466112 |
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| author | Yi-Chiao Teng Jiang Chen Wan-Bing Zhong Yuan-Hao Liu |
| author_facet | Yi-Chiao Teng Jiang Chen Wan-Bing Zhong Yuan-Hao Liu |
| author_sort | Yi-Chiao Teng |
| collection | DOAJ |
| description | Abstract Most treatment planning systems of boron neutron capture therapy perform dose calculations based on the assumption of a homogeneous boron distribution in tumors, which leads to dose distortion due to the difference between the tumor-to-normal tissue ratio (TNR) range measured in positron emission tomography images (PET) and the target delineation in computed tomography images of the treatment plan. The heterogeneous boron distribution in the target of the treatment plan can be obtained by image fusion. This study provides a way to quantify a heterogeneous boron distribution based on PET images. Theoretically, the same mean TNR for dose calculation by homogeneous or heterogeneous boron distribution should get almost the same mean dose. However, slightly different mean doses are found due to the partial volume effect for a small target volume. The wider the boron distribution is, the higher the impact on the dose-volume histogram distribution is. Dose distribution with homogeneous boron distribution may be overestimated in low boron uptake regions by wrong boron concentration and neutron flux depression. To accurately give the tumor prescription dose and achieve better tumor control, for low dose regions of the tumor should be considered more boron neutron capture therapy treatments or combined with other treatment modalities. The heterogeneous boron distribution must be taken into consideration to have an accurate dose estimation. Therefore, the way how medical physicists and clinicians process the TNR in gross tumor volume should be refined, and the method demonstrated in the work provides a good reference. |
| first_indexed | 2024-03-09T15:18:24Z |
| format | Article |
| id | doaj.art-4134eb7440374f9c808eb1f36b7b64d2 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-09T15:18:24Z |
| publishDate | 2023-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-4134eb7440374f9c808eb1f36b7b64d22023-11-26T12:57:05ZengNature PortfolioScientific Reports2045-23222023-09-0113111210.1038/s41598-023-42284-xCorrecting for the heterogeneous boron distribution in a tumor for BNCT dose calculationYi-Chiao Teng0Jiang Chen1Wan-Bing Zhong2Yuan-Hao Liu3Neuboron Therapy System Ltd.Neuboron Therapy System Ltd.Neuboron Therapy System Ltd.Neuboron Therapy System Ltd.Abstract Most treatment planning systems of boron neutron capture therapy perform dose calculations based on the assumption of a homogeneous boron distribution in tumors, which leads to dose distortion due to the difference between the tumor-to-normal tissue ratio (TNR) range measured in positron emission tomography images (PET) and the target delineation in computed tomography images of the treatment plan. The heterogeneous boron distribution in the target of the treatment plan can be obtained by image fusion. This study provides a way to quantify a heterogeneous boron distribution based on PET images. Theoretically, the same mean TNR for dose calculation by homogeneous or heterogeneous boron distribution should get almost the same mean dose. However, slightly different mean doses are found due to the partial volume effect for a small target volume. The wider the boron distribution is, the higher the impact on the dose-volume histogram distribution is. Dose distribution with homogeneous boron distribution may be overestimated in low boron uptake regions by wrong boron concentration and neutron flux depression. To accurately give the tumor prescription dose and achieve better tumor control, for low dose regions of the tumor should be considered more boron neutron capture therapy treatments or combined with other treatment modalities. The heterogeneous boron distribution must be taken into consideration to have an accurate dose estimation. Therefore, the way how medical physicists and clinicians process the TNR in gross tumor volume should be refined, and the method demonstrated in the work provides a good reference.https://doi.org/10.1038/s41598-023-42284-x |
| spellingShingle | Yi-Chiao Teng Jiang Chen Wan-Bing Zhong Yuan-Hao Liu Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation Scientific Reports |
| title | Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation |
| title_full | Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation |
| title_fullStr | Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation |
| title_full_unstemmed | Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation |
| title_short | Correcting for the heterogeneous boron distribution in a tumor for BNCT dose calculation |
| title_sort | correcting for the heterogeneous boron distribution in a tumor for bnct dose calculation |
| url | https://doi.org/10.1038/s41598-023-42284-x |
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