Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities

Bivalent metal ions induce formation of α-synuclein fibril polymorphs with different cytotoxicities

Abstract α-Synuclein (α-Syn) aggregates are key components of intracellular inclusion bodies characteristic of Parkinson’s disease (PD) and other synucleinopathies. Metal ions have been considered as the important etiological factors in PD since their interactions with α-Syn alter the kinetics of fi...

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Main Authors: Deyhim Atarod, Fatemeh Mamashli, Atiyeh Ghasemi, Faezeh Moosavi-Movahedi, Mitra Pirhaghi, Hadi Nedaei, Vladimir Muronetz, Thomas Haertlé, Jörg Tatzelt, Gholamhossein Riazi, Ali Akbar Saboury
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15472-4

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