A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation

A novel GRK2 inhibitor alleviates experimental arthritis through restraining Th17 cell differentiation

T helper type 17 (Th17) cell which is induced by interleukine-6 (IL-6)-signal transducers and activators of transcription 3 (STAT3) signaling is a central pro-inflammatory T cell subtype in rheumatoid arthritis (RA) and could be significantly reduced by paeoniflorin-6′-O-benzene sulfonate (CP-25) tr...

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Bibliographic Details
Main Authors: Juan Tao, Chunru Jiang, Paipai Guo, Huijuan Chen, Zhenduo Zhu, Tiantian Su, Weijie Zhou, Yu Tai, Chenchen Han, Yang Ma, Jingyu Chen, Wuyi Sun, Yuanyuan Wang, Wei Wei, Qingtong Wang
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Paeoniflorin-6′-O-benzene sulfonate
G protein coupled receptor 2
β-arrestin2
Th17
Rheumatoid arthritis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222013865

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http://www.sciencedirect.com/science/article/pii/S0753332222013865

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