Prognostic role of oxytocin receptor in colon adenocarcinoma
The oxytocin receptor (OXTR) is directly involved in the pathological mechanisms of multiple cancers, including breast cancer, prostate cancer, and ovarian cancer; however, the role of OXTR in the modulation of colon adenocarcinoma (COAD) growth, metastasis, and clinical prognosis remains to be eluc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
De Gruyter
2021-11-01
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| Series: | Open Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/med-2021-0387 |
| _version_ | 1811203000909168640 |
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| author | Sun Junjie Xu Zhenyu Mao Yong Zhang Ting Qin Yan Hua Dong |
| author_facet | Sun Junjie Xu Zhenyu Mao Yong Zhang Ting Qin Yan Hua Dong |
| author_sort | Sun Junjie |
| collection | DOAJ |
| description | The oxytocin receptor (OXTR) is directly involved in the pathological mechanisms of multiple cancers, including breast cancer, prostate cancer, and ovarian cancer; however, the role of OXTR in the modulation of colon adenocarcinoma (COAD) growth, metastasis, and clinical prognosis remains to be elucidated. This study used systematic bioinformatics analysis to explore the effects of OXTR on modulating COAD growth and prognosis in patients with COAD. Compared with normal tissues, OXTR mRNA level was higher in COAD tissues, which was associated with tumor progression. Elevated mRNA level of OXTR also indicated a poor prognosis in COAD patients. Furthermore, high mRNA level of OXTR was significantly associated with pathways involved in cell cycle regulation and signal transduction pathways, including the hedgehog, mTOR, TGF-β, and Wnt signaling pathways. OXTR expression was significantly correlated with the infiltration level of type 2T helper cell, central memory CD8 T cell, CD56 bright natural killer cell, activated CD8 T cell, activated B cell, and Type 1T helper cell. Moreover, silencing OXTR inhibited cell proliferation, migration, and invasion, and arrested the cell cycle. In conclusion, high mRNA level of OXTR indicates poor prognosis. |
| first_indexed | 2024-04-12T02:48:30Z |
| format | Article |
| id | doaj.art-413644ea71534e8096ed0da63e3ed336 |
| institution | Directory Open Access Journal |
| issn | 2391-5463 |
| language | English |
| last_indexed | 2024-04-12T02:48:30Z |
| publishDate | 2021-11-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Medicine |
| spelling | doaj.art-413644ea71534e8096ed0da63e3ed3362022-12-22T03:51:05ZengDe GruyterOpen Medicine2391-54632021-11-011611762177610.1515/med-2021-0387Prognostic role of oxytocin receptor in colon adenocarcinomaSun Junjie0Xu Zhenyu1Mao Yong2Zhang Ting3Qin Yan4Hua Dong5Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, P. R. ChinaDepartment of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, P. R. ChinaDepartment of Oncology, The Affiliated Hospital of Jiangnan University, No. 200, Huihe Road, Wuxi, 214000, Jiangsu, P. R. ChinaDepartment of Oncology, The Affiliated Hospital of Jiangnan University, No. 200, Huihe Road, Wuxi, 214000, Jiangsu, P. R. ChinaDepartment of Pathology, The Affiliated Hospital of Jiangnan University, No. 200, Huihe Road, Wuxi, 214000, Jiangsu, P. R. ChinaDepartment of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, Jiangsu, P. R. ChinaThe oxytocin receptor (OXTR) is directly involved in the pathological mechanisms of multiple cancers, including breast cancer, prostate cancer, and ovarian cancer; however, the role of OXTR in the modulation of colon adenocarcinoma (COAD) growth, metastasis, and clinical prognosis remains to be elucidated. This study used systematic bioinformatics analysis to explore the effects of OXTR on modulating COAD growth and prognosis in patients with COAD. Compared with normal tissues, OXTR mRNA level was higher in COAD tissues, which was associated with tumor progression. Elevated mRNA level of OXTR also indicated a poor prognosis in COAD patients. Furthermore, high mRNA level of OXTR was significantly associated with pathways involved in cell cycle regulation and signal transduction pathways, including the hedgehog, mTOR, TGF-β, and Wnt signaling pathways. OXTR expression was significantly correlated with the infiltration level of type 2T helper cell, central memory CD8 T cell, CD56 bright natural killer cell, activated CD8 T cell, activated B cell, and Type 1T helper cell. Moreover, silencing OXTR inhibited cell proliferation, migration, and invasion, and arrested the cell cycle. In conclusion, high mRNA level of OXTR indicates poor prognosis.https://doi.org/10.1515/med-2021-0387oxytocin receptorcolorectal cancerthe cancer genome atlaspoor prognosisimmune infiltration |
| spellingShingle | Sun Junjie Xu Zhenyu Mao Yong Zhang Ting Qin Yan Hua Dong Prognostic role of oxytocin receptor in colon adenocarcinoma Open Medicine oxytocin receptor colorectal cancer the cancer genome atlas poor prognosis immune infiltration |
| title | Prognostic role of oxytocin receptor in colon adenocarcinoma |
| title_full | Prognostic role of oxytocin receptor in colon adenocarcinoma |
| title_fullStr | Prognostic role of oxytocin receptor in colon adenocarcinoma |
| title_full_unstemmed | Prognostic role of oxytocin receptor in colon adenocarcinoma |
| title_short | Prognostic role of oxytocin receptor in colon adenocarcinoma |
| title_sort | prognostic role of oxytocin receptor in colon adenocarcinoma |
| topic | oxytocin receptor colorectal cancer the cancer genome atlas poor prognosis immune infiltration |
| url | https://doi.org/10.1515/med-2021-0387 |
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