The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia
Purpose: to develop preventive measures and reasonable therapy of pathological processes in the cervix uteri based on detection of methylation of tumor suppressor genes and groups at high-risk of cancer among patients of reproductive age with benign and premalignant cervical processes. Effectiveness...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Peoples’ Friendship University of Russia (RUDN University)
2014-12-01
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| Series: | RUDN Journal of Medicine |
| Subjects: | |
| Online Access: | http://journals.rudn.ru/medicine/article/view/3143 |
| _version_ | 1818130081488306176 |
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| author | I S Sidorova A L Unanyan V M Drukh E L Muyzhnek |
| author_facet | I S Sidorova A L Unanyan V M Drukh E L Muyzhnek |
| author_sort | I S Sidorova |
| collection | DOAJ |
| description | Purpose: to develop preventive measures and reasonable therapy of pathological processes in the cervix uteri based on detection of methylation of tumor suppressor genes and groups at high-risk of cancer among patients of reproductive age with benign and premalignant cervical processes. Effectiveness of complex pathogenetic treatment of the cervix uteri has been evaluated in 127 women of reproductive age with benign and premalignant cervical processes before and after the combined treatment with a pharmaceutical composition containing active substance epigallocatechin-3-gallate (EGCG). Shown that pharmaceutical composition containing EGCG contributes demethylation of the tumor suppressor genes that confirm powerful oncoprotector action in treating precancerous lesions. One year after the complex combined therapy (including surgery) with pharmaceutical composition containing EGCG, recurrent cervical pathological processes have not been detected in patients with benign lesions, CIN I and CIN II. |
| first_indexed | 2024-12-11T07:59:22Z |
| format | Article |
| id | doaj.art-4138a53a5427430e9ddabe8c8fc1e61d |
| institution | Directory Open Access Journal |
| issn | 2313-0245 2313-0261 |
| language | English |
| last_indexed | 2024-12-11T07:59:22Z |
| publishDate | 2014-12-01 |
| publisher | Peoples’ Friendship University of Russia (RUDN University) |
| record_format | Article |
| series | RUDN Journal of Medicine |
| spelling | doaj.art-4138a53a5427430e9ddabe8c8fc1e61d2022-12-22T01:15:09ZengPeoples’ Friendship University of Russia (RUDN University)RUDN Journal of Medicine2313-02452313-02612014-12-010382873143The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasiaI S Sidorova0A L Unanyan1V M Drukh2E L Muyzhnek3ФГОУ ВПО «Первый МГМУ им. И.М. Сеченова»ФГОУ ВПО «Первый МГМУ им. И.М. Сеченова»ФГОУ ВПО «Российский университет дружбы народов»ЗАО «МираксБиоФарма»Purpose: to develop preventive measures and reasonable therapy of pathological processes in the cervix uteri based on detection of methylation of tumor suppressor genes and groups at high-risk of cancer among patients of reproductive age with benign and premalignant cervical processes. Effectiveness of complex pathogenetic treatment of the cervix uteri has been evaluated in 127 women of reproductive age with benign and premalignant cervical processes before and after the combined treatment with a pharmaceutical composition containing active substance epigallocatechin-3-gallate (EGCG). Shown that pharmaceutical composition containing EGCG contributes demethylation of the tumor suppressor genes that confirm powerful oncoprotector action in treating precancerous lesions. One year after the complex combined therapy (including surgery) with pharmaceutical composition containing EGCG, recurrent cervical pathological processes have not been detected in patients with benign lesions, CIN I and CIN II.http://journals.rudn.ru/medicine/article/view/3143профилактика ракаметилирование геновEGСG |
| spellingShingle | I S Sidorova A L Unanyan V M Drukh E L Muyzhnek The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia RUDN Journal of Medicine профилактика рака метилирование генов EGСG |
| title | The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia |
| title_full | The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia |
| title_fullStr | The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia |
| title_full_unstemmed | The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia |
| title_short | The effects of new pharmaceutical composition containing Epigallocatechin-3-Gallate (EGCG) to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia |
| title_sort | effects of new pharmaceutical composition containing epigallocatechin 3 gallate egcg to inhibit methylation of the tumor supressor genes in patients with cervical intraepithelial neoplasia |
| topic | профилактика рака метилирование генов EGСG |
| url | http://journals.rudn.ru/medicine/article/view/3143 |
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