TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

TonEBP regulates the hyperosmotic expression of aquaporin 1 and 5 in the intervertebral disc

Abstract The central region of the intervertebral disc (IVD) is rich in proteoglycans, leading to a hyperosmotic environment, which fluctuates with daily loading. The cells of the nucleus pulposus (NP cells) have adapted to this environment via the function of tonicity enhancer binding protein (TonE...

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Bibliographic Details
Main Authors: J. W. Snuggs, S. Tessier, R. A. B. Bunning, I. M. Shapiro, M. V. Risbud, C. L. Le Maitre
Format: Article
Language:English
Published: Nature Portfolio 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-81838-9

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