Development and Application of a Dissolution-Transfer-Partitioning System (DTPS) for Biopharmaceutical Drug Characterization

Development and Application of a Dissolution-Transfer-Partitioning System (DTPS) for Biopharmaceutical Drug Characterization

A variety of in vitro dissolution and gastrointestinal transfer models have been developed aiming to predict drug supersaturation and precipitation. Further, biphasic, one-vessel in vitro systems are increasingly applied to simulate drug absorption in vitro. However, to date, there is a lack of comb...

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Bibliographic Details
Main Authors: Christian Jede, Laura J. Henze, Kirstin Meiners, Malte Bogdahn, Marcel Wedel, Valeria van Axel
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
in vitro dissolution testing
in vitro dissolution methods
in vivo dissolution
oral drug absorption
oral bioavailability
gastrointestinal
Online Access:https://www.mdpi.com/1999-4923/15/4/1069

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