The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells.
Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0282347 |
| _version_ | 1827963365387927552 |
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| author | Shreya Bhattacharya Alec Jacob Maupin Anders Grønnegaard Schlosser Ernst-Martin Füchtbauer Yamel Cardona Gloria Alexander N R Weber Uffe Holmskov Jesper Bonnet Moeller Steven P Templeton |
| author_facet | Shreya Bhattacharya Alec Jacob Maupin Anders Grønnegaard Schlosser Ernst-Martin Füchtbauer Yamel Cardona Gloria Alexander N R Weber Uffe Holmskov Jesper Bonnet Moeller Steven P Templeton |
| author_sort | Shreya Bhattacharya |
| collection | DOAJ |
| description | Chitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that binds chitin, is found in human lung epithelium and modulates lung epithelial inflammatory responses to A. fumigatus cell wall polysaccharides. We previously reported the detrimental role of FIBCD1 in a murine model of pulmonary invasive aspergillosis. However, the effect that chitin and chitin-containing A. fumigatus conidia exerts on lung epithelium following exposure through FIBCD1 is not yet fully explored. Using both in vitro and in vivo strategies, we examined how lung and lung epithelial gene expression are modified after exposure to fungal conidia or chitin fragments in the presence or absence of FIBCD1. FIBCD1 expression was associated with a decrease in inflammatory cytokines with increasing size of chitin (dimer-oligomer). Thus, our results demonstrate that FIBCD1 expression modulates cytokine and chemokine expression in response to A. fumigatus conidia that is modified by the presence of chitin particles. |
| first_indexed | 2024-04-09T16:56:50Z |
| format | Article |
| id | doaj.art-4139864ba14240e6bd5d4d61ecd9daf4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-09T16:56:50Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4139864ba14240e6bd5d4d61ecd9daf42023-04-21T05:35:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01183e028234710.1371/journal.pone.0282347The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells.Shreya BhattacharyaAlec Jacob MaupinAnders Grønnegaard SchlosserErnst-Martin FüchtbauerYamel Cardona GloriaAlexander N R WeberUffe HolmskovJesper Bonnet MoellerSteven P TempletonChitin, a polysaccharide, is ubiquitously found in nature and has been known to be an active immunogen in mammals, and interacts with Toll-like, mannose and glucan receptors, to induce cytokine and chemokine secretions. FIBCD1 is a tetrameric type II transmembrane endocytic vertebrate receptor that binds chitin, is found in human lung epithelium and modulates lung epithelial inflammatory responses to A. fumigatus cell wall polysaccharides. We previously reported the detrimental role of FIBCD1 in a murine model of pulmonary invasive aspergillosis. However, the effect that chitin and chitin-containing A. fumigatus conidia exerts on lung epithelium following exposure through FIBCD1 is not yet fully explored. Using both in vitro and in vivo strategies, we examined how lung and lung epithelial gene expression are modified after exposure to fungal conidia or chitin fragments in the presence or absence of FIBCD1. FIBCD1 expression was associated with a decrease in inflammatory cytokines with increasing size of chitin (dimer-oligomer). Thus, our results demonstrate that FIBCD1 expression modulates cytokine and chemokine expression in response to A. fumigatus conidia that is modified by the presence of chitin particles.https://doi.org/10.1371/journal.pone.0282347 |
| spellingShingle | Shreya Bhattacharya Alec Jacob Maupin Anders Grønnegaard Schlosser Ernst-Martin Füchtbauer Yamel Cardona Gloria Alexander N R Weber Uffe Holmskov Jesper Bonnet Moeller Steven P Templeton The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. PLoS ONE |
| title | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. |
| title_full | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. |
| title_fullStr | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. |
| title_full_unstemmed | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. |
| title_short | The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells. |
| title_sort | role of fibcd1 in response to aspergillus fumigatus in lung epithelial cells |
| url | https://doi.org/10.1371/journal.pone.0282347 |
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