CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS
To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology, sixty patients have been examined in five equal groups, i.e., BA; hypothyroidism; thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as ...
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| Format: | Article |
| Language: | Russian |
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St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists
2014-07-01
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| Series: | Медицинская иммунология |
| Subjects: | |
| Online Access: | https://www.mimmun.ru/mimmun/article/view/97 |
| _version_ | 1826534377959456768 |
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| author | I. A. Kamaeva N. L. Shaporova I. M. Gaiduk |
| author_facet | I. A. Kamaeva N. L. Shaporova I. M. Gaiduk |
| author_sort | I. A. Kamaeva |
| collection | DOAJ |
| description | To reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology, sixty patients have been examined in five equal groups, i.e., BA; hypothyroidism; thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more frequently in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged in BA patients, than in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum IgE levels were much increased in the group with BA + hyperthyroidism. The lowest IL-4/IFNγ ratio was revealed in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher in BA + hyperthyroidism group, than in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions dominating in BA, whereas concomitant hypothyroidism may cause a reduction of Th2 immune response. |
| first_indexed | 2024-03-08T05:51:27Z |
| format | Article |
| id | doaj.art-413b764a91044a169dd4b7546d900890 |
| institution | Directory Open Access Journal |
| issn | 1563-0625 2313-741X |
| language | Russian |
| last_indexed | 2025-03-14T02:22:04Z |
| publishDate | 2014-07-01 |
| publisher | St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists |
| record_format | Article |
| series | Медицинская иммунология |
| spelling | doaj.art-413b764a91044a169dd4b7546d9008902025-03-11T17:59:00ZrusSt. Petersburg branch of the Russian Association of Allergologists and Clinical ImmunologistsМедицинская иммунология1563-06252313-741X2014-07-0115214715410.15789/1563-0625-2013-2-147-15495CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERSI. A. Kamaeva0N. L. Shaporova1I. M. Gaiduk2St. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. PetersburgSt. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. PetersburgSt. Petersburg State I.P. Pavlov Medical University, Russian Ministry of Health Care, St. PetersburgTo reveal clinical and immunological features of bronchial asthma (BA) combined with thyroid gland pathology, sixty patients have been examined in five equal groups, i.e., BA; hypothyroidism; thyrotoxicosis; BA + hypothyroidism; BA + thyrotoxicosis. We assessed serum IgE, IgG levels, as wekk as IL-4/IFNγ, IL-4/IL-1, and IL-1/IL-6 ratios. Clinical exacerbations were observed more frequently in BA + hypothyroidism, as compared with BA patients. Remissions of BA were more prolonged in BA patients, than in groups with BA + hypothyroidism, or BA + hyperthyroidism. Serum IgE levels were much increased in the group with BA + hyperthyroidism. The lowest IL-4/IFNγ ratio was revealed in BA + hypothyroidism group versus BA and BA + hyperthyroidism groups. IL-4/IL-1 ratio was higher in BA + hyperthyroidism group, than in BA and BA + hypothyroidism. Co-existence of hyperthyroidism with BA seems to enhance Th2 immune reactions dominating in BA, whereas concomitant hypothyroidism may cause a reduction of Th2 immune response.https://www.mimmun.ru/mimmun/article/view/97бронхиальная астма, гипотиреозтиреотоксикозинтерлейкиниммуноглобулин e |
| spellingShingle | I. A. Kamaeva N. L. Shaporova I. M. Gaiduk CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS Медицинская иммунология бронхиальная астма, гипотиреоз тиреотоксикоз интерлейкин иммуноглобулин e |
| title | CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS |
| title_full | CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS |
| title_fullStr | CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS |
| title_full_unstemmed | CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS |
| title_short | CLINICAL AND IMMUNOLOGICAL FEATURES OF BRONCHIAL ASTHMA ACCOMPANIED BY THYROID GLAND DISORDERS |
| title_sort | clinical and immunological features of bronchial asthma accompanied by thyroid gland disorders |
| topic | бронхиальная астма, гипотиреоз тиреотоксикоз интерлейкин иммуноглобулин e |
| url | https://www.mimmun.ru/mimmun/article/view/97 |
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