Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy
<p>Abstract</p> <p>In the latest years, innovative nanomaterials have attracted a dramatic and exponentially increasing interest, in particular for their potential applications in the biomedical field. In this paper, we reported our findings on the cytocompatibility of barium titan...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2010-01-01
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| Series: | Nanoscale Research Letters |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1007/s11671-010-9607-0 |
| _version_ | 1797762447326576640 |
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| author | Danti Serena D’Alessandro Delfo Petrini Mario Moscato Stefania Ciofani Gianni Menciassi Arianna |
| author_facet | Danti Serena D’Alessandro Delfo Petrini Mario Moscato Stefania Ciofani Gianni Menciassi Arianna |
| author_sort | Danti Serena |
| collection | DOAJ |
| description | <p>Abstract</p> <p>In the latest years, innovative nanomaterials have attracted a dramatic and exponentially increasing interest, in particular for their potential applications in the biomedical field. In this paper, we reported our findings on the cytocompatibility of barium titanate nanoparticles (BTNPs), an extremely interesting ceramic material. A rational and systematic study of BTNP cytocompatibility was performed, using a dispersion method based on a non-covalent binding to glycol-chitosan, which demonstrated the optimal cytocompatibility of this nanomaterial even at high concentration (100 μg/ml). Moreover, we showed that the efficiency of doxorubicin, a widely used chemotherapy drug, is highly enhanced following the complexation with BTNPs. Our results suggest that innovative ceramic nanomaterials such as BTNPs can be realistically exploited as alternative cellular nanovectors.</p> |
| first_indexed | 2024-03-12T19:27:30Z |
| format | Article |
| id | doaj.art-413c5a7eab6044db86392891dd36ff7b |
| institution | Directory Open Access Journal |
| issn | 1931-7573 1556-276X |
| language | English |
| last_indexed | 2024-03-12T19:27:30Z |
| publishDate | 2010-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Nanoscale Research Letters |
| spelling | doaj.art-413c5a7eab6044db86392891dd36ff7b2023-08-02T04:48:01ZengSpringerOpenNanoscale Research Letters1931-75731556-276X2010-01-015710931101Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer TherapyDanti SerenaD’Alessandro DelfoPetrini MarioMoscato StefaniaCiofani GianniMenciassi Arianna<p>Abstract</p> <p>In the latest years, innovative nanomaterials have attracted a dramatic and exponentially increasing interest, in particular for their potential applications in the biomedical field. In this paper, we reported our findings on the cytocompatibility of barium titanate nanoparticles (BTNPs), an extremely interesting ceramic material. A rational and systematic study of BTNP cytocompatibility was performed, using a dispersion method based on a non-covalent binding to glycol-chitosan, which demonstrated the optimal cytocompatibility of this nanomaterial even at high concentration (100 μg/ml). Moreover, we showed that the efficiency of doxorubicin, a widely used chemotherapy drug, is highly enhanced following the complexation with BTNPs. Our results suggest that innovative ceramic nanomaterials such as BTNPs can be realistically exploited as alternative cellular nanovectors.</p>http://dx.doi.org/10.1007/s11671-010-9607-0Barium titanate nanoparticlesGlycol-chitosanDoxorubicinNeuroblastomaCancer therapy |
| spellingShingle | Danti Serena D’Alessandro Delfo Petrini Mario Moscato Stefania Ciofani Gianni Menciassi Arianna Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy Nanoscale Research Letters Barium titanate nanoparticles Glycol-chitosan Doxorubicin Neuroblastoma Cancer therapy |
| title | Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy |
| title_full | Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy |
| title_fullStr | Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy |
| title_full_unstemmed | Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy |
| title_short | Barium Titanate Nanoparticles: Highly Cytocompatible Dispersions in Glycol-chitosan and Doxorubicin Complexes for Cancer Therapy |
| title_sort | barium titanate nanoparticles highly cytocompatible dispersions in glycol chitosan and doxorubicin complexes for cancer therapy |
| topic | Barium titanate nanoparticles Glycol-chitosan Doxorubicin Neuroblastoma Cancer therapy |
| url | http://dx.doi.org/10.1007/s11671-010-9607-0 |
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