Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysis
BackgroundCow’s milk protein allergy (CMPA) occurs commonly in infants. While the long-term efficacy of amino acid formulas for managing CMPA is well-established, there is limited data on the short-term symptom improvement of using amino acid formula (AAF).ObjectiveThis study aimed to determine the...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-06-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2023.1208334/full |
| _version_ | 1827921061452185600 |
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| author | Michael J. Wilsey Michael J. Wilsey Jessica V. Baran Luke Lamos Jesse Beacker Jared Florio Lea Oliveros Panida Sriaroon Jerry M. Brown Jon A. Vanderhoof |
| author_facet | Michael J. Wilsey Michael J. Wilsey Jessica V. Baran Luke Lamos Jesse Beacker Jared Florio Lea Oliveros Panida Sriaroon Jerry M. Brown Jon A. Vanderhoof |
| author_sort | Michael J. Wilsey |
| collection | DOAJ |
| description | BackgroundCow’s milk protein allergy (CMPA) occurs commonly in infants. While the long-term efficacy of amino acid formulas for managing CMPA is well-established, there is limited data on the short-term symptom improvement of using amino acid formula (AAF).ObjectiveThis study aimed to determine the short-term effects of managing suspected CMPA in infants aged 6 months and under using a commercial AAF.MethodsHealthcare providers who treated infants with suspected CMPA aged 6 months or younger (n = 104) provided de-identified survey data in this prospective study. Healthcare providers scored symptoms for severity from 0 to 3 (none, low, moderate, severe) before using a commercial AAF at Visit 1 and at Visit 2 (3–6 weeks later).ResultsGastrointestinal (94%), skin (87%), respiratory (86%), and uncategorized symptoms (89%) improved from AAF initiation, and these findings were consistent across different follow-up visit durations.ConclusionThis study is the most extensive prospective analysis conducted in the United States examining the short-term change in suspected CMPA symptoms using an AAF. These findings suggest that AAF may decrease the severity of suspected CMPA symptoms in infants 6 months or younger, often by the next follow-up visit. Further randomized controlled trials are required to confirm these initial findings. |
| first_indexed | 2024-03-13T04:20:34Z |
| format | Article |
| id | doaj.art-413fd2e9d9174408b7cf6624f18995ec |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-03-13T04:20:34Z |
| publishDate | 2023-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-413fd2e9d9174408b7cf6624f18995ec2023-06-20T10:04:55ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2023-06-011010.3389/fnut.2023.12083341208334Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysisMichael J. Wilsey0Michael J. Wilsey1Jessica V. Baran2Luke Lamos3Jesse Beacker4Jared Florio5Lea Oliveros6Panida Sriaroon7Jerry M. Brown8Jon A. Vanderhoof9Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, FL, United StatesPediatric Gastroenterology, Hepatology, and Nutrition of Florida, St. Petersburg, FL, United StatesOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL, United StatesOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL, United StatesOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL, United StatesOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL, United StatesPediatric Gastroenterology, Hepatology, and Nutrition of Florida, St. Petersburg, FL, United StatesDepartment of Pediatrics, Division of Allergy and Immunology, University of South Florida Morsani College of Medicine, Tampa, FL, United StatesOffice of Medical Education, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, FL, United StatesDepartment of Gastroenterology Hepatology and Nutrition, Boys Town Hospital, Boys Town, NE, United StatesBackgroundCow’s milk protein allergy (CMPA) occurs commonly in infants. While the long-term efficacy of amino acid formulas for managing CMPA is well-established, there is limited data on the short-term symptom improvement of using amino acid formula (AAF).ObjectiveThis study aimed to determine the short-term effects of managing suspected CMPA in infants aged 6 months and under using a commercial AAF.MethodsHealthcare providers who treated infants with suspected CMPA aged 6 months or younger (n = 104) provided de-identified survey data in this prospective study. Healthcare providers scored symptoms for severity from 0 to 3 (none, low, moderate, severe) before using a commercial AAF at Visit 1 and at Visit 2 (3–6 weeks later).ResultsGastrointestinal (94%), skin (87%), respiratory (86%), and uncategorized symptoms (89%) improved from AAF initiation, and these findings were consistent across different follow-up visit durations.ConclusionThis study is the most extensive prospective analysis conducted in the United States examining the short-term change in suspected CMPA symptoms using an AAF. These findings suggest that AAF may decrease the severity of suspected CMPA symptoms in infants 6 months or younger, often by the next follow-up visit. Further randomized controlled trials are required to confirm these initial findings.https://www.frontiersin.org/articles/10.3389/fnut.2023.1208334/fullcow’s milk protein allergy (CMPA)milk hypersensitivityeczemainfant nutritionamino acid formulaZSMoments |
| spellingShingle | Michael J. Wilsey Michael J. Wilsey Jessica V. Baran Luke Lamos Jesse Beacker Jared Florio Lea Oliveros Panida Sriaroon Jerry M. Brown Jon A. Vanderhoof Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysis Frontiers in Nutrition cow’s milk protein allergy (CMPA) milk hypersensitivity eczema infant nutrition amino acid formula ZSMoments |
| title | Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysis |
| title_full | Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysis |
| title_fullStr | Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysis |
| title_full_unstemmed | Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysis |
| title_short | Short-term symptom improvement in infants with suspected cow’s milk protein allergy using amino acid formula: a prospective cohort analysis |
| title_sort | short term symptom improvement in infants with suspected cow s milk protein allergy using amino acid formula a prospective cohort analysis |
| topic | cow’s milk protein allergy (CMPA) milk hypersensitivity eczema infant nutrition amino acid formula ZSMoments |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2023.1208334/full |
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