Is circulating survivin altered in acromegaly?
Acromegaly is a chronic disorder which is characterized by growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in tissue samples of different benign and ma...
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| Format: | Article |
| Language: | English |
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Society of Turaz Bilim
2018-06-01
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| Series: | Medicine Science |
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| Online Access: | http://www.ejmanager.com/fulltextpdf.php?mno=282973 |
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| author | Esra Ademoglu Erdal Dilekci Zehra Candan Suheyla Gorar Mutlu Niyazoglu, Ayse Carlioglu Faruk Yildiz Idris Baydar Abdulmuttalip Aslan |
| author_facet | Esra Ademoglu Erdal Dilekci Zehra Candan Suheyla Gorar Mutlu Niyazoglu, Ayse Carlioglu Faruk Yildiz Idris Baydar Abdulmuttalip Aslan |
| author_sort | Esra Ademoglu |
| collection | DOAJ |
| description | Acromegaly is a chronic disorder which is characterized by growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in tissue samples of different benign and malignant human tumors. This study is intended to determine circulating levels of survivin in newly diagnosed acromegaly patients with somatotroph adenomas. 19 newly diagnosed acromegaly patients with somatotroph adenomas were inclu-ded in the study. Concurrently, 19 healthy individuals were included as control group. Serum survivin levels, GH, insulin like growth factor-1 (IGF-1) and, some other biochemical parame-ters as fasting glucose, creatinine, alanine aminotransferase, cholesterol, triglyceride, high den-sity lipoprotein cholesterol, low density lipoprotein cholesterol were measured in each subject. Correlation analysis was performed between survivin and GH, IGF-1. Serum survivin levels tended to be higher in acromegaly group, but this was not reach statistical significance (p>0.05). Serum survivin levels were comparable among acromegaly patients and controls. Neither GH nor IGF-1 correlated with serum survivin. Larger scale studies are needed concerning the circulating levels of survivin in patients with acromegaly. [Med-Science 2018; 7(2.000): 265-8] |
| first_indexed | 2024-03-08T06:48:00Z |
| format | Article |
| id | doaj.art-414228501895455fafc32b96a5f529a0 |
| institution | Directory Open Access Journal |
| issn | 2147-0634 |
| language | English |
| last_indexed | 2024-03-08T06:48:00Z |
| publishDate | 2018-06-01 |
| publisher | Society of Turaz Bilim |
| record_format | Article |
| series | Medicine Science |
| spelling | doaj.art-414228501895455fafc32b96a5f529a02024-02-03T07:29:03ZengSociety of Turaz BilimMedicine Science2147-06342018-06-0172265810.5455/medscience.2017.06.8681282973Is circulating survivin altered in acromegaly?Esra Ademoglu0Erdal DilekciZehra CandanSuheyla GorarMutlu Niyazoglu, Ayse CarliogluFaruk YildizIdris BaydarAbdulmuttalip AslanAbant Izzet Baysal University School of Medicine, Department of Endocrinology and Metabolism, Bolu, Turkey Abant Izzet Baysal University School of Medicine, Department of Physical Medicine and Rehabilitation Bolu, Turkey Medical Park Hospitals, Department of Endocrinology and Metabolism, Ankara, Turkey Department of Antalya Training and Educational Hospital, Antalya, Turkey Istanbul University Cerrahpasa School of Medicine, Department of Endocrinology and Metabolism, Istanbul, Turkey Erzurum Training and Educational Hospital Department of Endocrinology and Metabolism, Erzurum, Turkey Erzurum Training and Educational Hospital, Division of Internal Medicine Erzurum, TurkeyAcromegaly is a chronic disorder which is characterized by growth hormone (GH) excess. In most of cases, GH hypersecretion is derived from somatotroph cell tumors. Survivin is a member of apoptosis protein family, which was recently showed to be expressed in tissue samples of different benign and malignant human tumors. This study is intended to determine circulating levels of survivin in newly diagnosed acromegaly patients with somatotroph adenomas. 19 newly diagnosed acromegaly patients with somatotroph adenomas were inclu-ded in the study. Concurrently, 19 healthy individuals were included as control group. Serum survivin levels, GH, insulin like growth factor-1 (IGF-1) and, some other biochemical parame-ters as fasting glucose, creatinine, alanine aminotransferase, cholesterol, triglyceride, high den-sity lipoprotein cholesterol, low density lipoprotein cholesterol were measured in each subject. Correlation analysis was performed between survivin and GH, IGF-1. Serum survivin levels tended to be higher in acromegaly group, but this was not reach statistical significance (p>0.05). Serum survivin levels were comparable among acromegaly patients and controls. Neither GH nor IGF-1 correlated with serum survivin. Larger scale studies are needed concerning the circulating levels of survivin in patients with acromegaly. [Med-Science 2018; 7(2.000): 265-8]http://www.ejmanager.com/fulltextpdf.php?mno=282973Acromegalysurvivinapoptosis protein family |
| spellingShingle | Esra Ademoglu Erdal Dilekci Zehra Candan Suheyla Gorar Mutlu Niyazoglu, Ayse Carlioglu Faruk Yildiz Idris Baydar Abdulmuttalip Aslan Is circulating survivin altered in acromegaly? Medicine Science Acromegaly survivin apoptosis protein family |
| title | Is circulating survivin altered in acromegaly? |
| title_full | Is circulating survivin altered in acromegaly? |
| title_fullStr | Is circulating survivin altered in acromegaly? |
| title_full_unstemmed | Is circulating survivin altered in acromegaly? |
| title_short | Is circulating survivin altered in acromegaly? |
| title_sort | is circulating survivin altered in acromegaly |
| topic | Acromegaly survivin apoptosis protein family |
| url | http://www.ejmanager.com/fulltextpdf.php?mno=282973 |
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