Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with Tetrachloride
Regarding the antioxidant, anti-inflammatory, and antibacterial effects of Salvia officnalis (S. officinalis) extracts and the use of medicinal herbs as an alternative to chemical drugs, this study aimed to evaluate the enzymatic changes and reduction of hepatocyte damage in mice poisoned with carbo...
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| Format: | Article |
| Language: | English |
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Razi Vaccine and Serum Research Institute
2021-12-01
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| Series: | Archives of Razi Institute |
| Subjects: | |
| Online Access: | https://archrazi.areeo.ac.ir/article_125102_5883606e3ac8b9e11040373363113700.pdf |
| _version_ | 1818242047788711936 |
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| author | R Kadhim N. H Ali D Aziz Ibrahim |
| author_facet | R Kadhim N. H Ali D Aziz Ibrahim |
| author_sort | R Kadhim |
| collection | DOAJ |
| description | Regarding the antioxidant, anti-inflammatory, and antibacterial effects of Salvia officnalis (S. officinalis) extracts and the use of medicinal herbs as an alternative to chemical drugs, this study aimed to evaluate the enzymatic changes and reduction of hepatocyte damage in mice poisoned with carbon tetrachloride (CCl4) after treatment with aqueous and alcoholic extract of Salvia officnalis. A total of 40 adult male mice were divided into eight groups including six experimental, one negative, and one positive control group, which were exposed to CCl4 at the concentration of 2.3 mg/kg. The active compounds in the alcoholic and aqueous extracts of S. officinalis were obtained using high-performance liquid chromatography. Subsequently, S. officinalis extract in 100, 200, and 300 mg /kg doses were fed orally to mice for six days. The enzymes (GST, ALP, ALT, AST, and MDA) were determined in mice serum. The study results showed that enzyme activity was significantly decreased in the group treated with S. officinalis extract, and the concentration of 300mg/kg proved to be most effective. In addition, it was indicated that the alcoholic extract had a higher effect than the aqueous extract, which might be due to the greater amount of active compounds in the alcoholic extract. The improving effects of S. officinalis can be attributed to the bioactive components with antioxidant properties that inhibit the damaging effects of free radicals, chemical drugs, and tissue damage. |
| first_indexed | 2024-12-12T13:39:01Z |
| format | Article |
| id | doaj.art-414264591a7f4fb8904410755cda1edb |
| institution | Directory Open Access Journal |
| issn | 0365-3439 2008-9872 |
| language | English |
| last_indexed | 2024-12-12T13:39:01Z |
| publishDate | 2021-12-01 |
| publisher | Razi Vaccine and Serum Research Institute |
| record_format | Article |
| series | Archives of Razi Institute |
| spelling | doaj.art-414264591a7f4fb8904410755cda1edb2022-12-22T00:22:52ZengRazi Vaccine and Serum Research InstituteArchives of Razi Institute0365-34392008-98722021-12-017661777178610.22092/ari.2021.356239.1812125102Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with TetrachlorideR Kadhim0N. H Ali1D Aziz Ibrahim2Department of Chemical, College of Science, Tikrit University, Tikrit, IraqDepartment of Chemical, College of Science, Tikrit University, Tikrit, IraqDepartment of Chemical, College of Science, Tikrit University, Tikrit, IraqRegarding the antioxidant, anti-inflammatory, and antibacterial effects of Salvia officnalis (S. officinalis) extracts and the use of medicinal herbs as an alternative to chemical drugs, this study aimed to evaluate the enzymatic changes and reduction of hepatocyte damage in mice poisoned with carbon tetrachloride (CCl4) after treatment with aqueous and alcoholic extract of Salvia officnalis. A total of 40 adult male mice were divided into eight groups including six experimental, one negative, and one positive control group, which were exposed to CCl4 at the concentration of 2.3 mg/kg. The active compounds in the alcoholic and aqueous extracts of S. officinalis were obtained using high-performance liquid chromatography. Subsequently, S. officinalis extract in 100, 200, and 300 mg /kg doses were fed orally to mice for six days. The enzymes (GST, ALP, ALT, AST, and MDA) were determined in mice serum. The study results showed that enzyme activity was significantly decreased in the group treated with S. officinalis extract, and the concentration of 300mg/kg proved to be most effective. In addition, it was indicated that the alcoholic extract had a higher effect than the aqueous extract, which might be due to the greater amount of active compounds in the alcoholic extract. The improving effects of S. officinalis can be attributed to the bioactive components with antioxidant properties that inhibit the damaging effects of free radicals, chemical drugs, and tissue damage.https://archrazi.areeo.ac.ir/article_125102_5883606e3ac8b9e11040373363113700.pdfalcoholic extractaqueous extractccl4enzymatic effectivesalvia officnalis |
| spellingShingle | R Kadhim N. H Ali D Aziz Ibrahim Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with Tetrachloride Archives of Razi Institute alcoholic extract aqueous extract ccl4 enzymatic effective salvia officnalis |
| title | Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with Tetrachloride |
| title_full | Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with Tetrachloride |
| title_fullStr | Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with Tetrachloride |
| title_full_unstemmed | Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with Tetrachloride |
| title_short | Enzymatic Effectiveness of Alcoholic and Aqueous Extract of Salvia Officinalis in Mice Poisoned with Tetrachloride |
| title_sort | enzymatic effectiveness of alcoholic and aqueous extract of salvia officinalis in mice poisoned with tetrachloride |
| topic | alcoholic extract aqueous extract ccl4 enzymatic effective salvia officnalis |
| url | https://archrazi.areeo.ac.ir/article_125102_5883606e3ac8b9e11040373363113700.pdf |
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