Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens.
The strategies for developing rotavirus (RV) vaccines have always been controversial. At present, both the monovalent RV vaccine and the multivalent RV vaccine have displayed excellent safety and efficacy against RV infection and shown cross-reactive immunity, which laid the question whether the mul...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5313208?pdf=render |
| _version_ | 1819263867637727232 |
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| author | Kai Mi Xia Ou Lili Guo Jing Ye Jinyuan Wu Shan Yi Xianglian Niu Xiaoqin Sun Hongjun Li Maosheng Sun |
| author_facet | Kai Mi Xia Ou Lili Guo Jing Ye Jinyuan Wu Shan Yi Xianglian Niu Xiaoqin Sun Hongjun Li Maosheng Sun |
| author_sort | Kai Mi |
| collection | DOAJ |
| description | The strategies for developing rotavirus (RV) vaccines have always been controversial. At present, both the monovalent RV vaccine and the multivalent RV vaccine have displayed excellent safety and efficacy against RV infection and shown cross-reactive immunity, which laid the question whether the multivalent RV vaccine could be replaced by the monovalent RV vaccine. In this study, we focused on comparing the immunogenicity (serum neutralization activity and protection against homotypic and heterotypic RVs' challenge) of individual standard RV strains (monovalent RV immunogens) and different combinations of them (multivalent RV immunogens). In result, RV immunogens showed general immunogenicity and heterotypic reaction but the multivalent RV immunogens exhibited greater serum neutralization activity and stronger heterotypic reaction than the monovalent RV immunogens (P<0.05). As to the protection, the multivalent RV immunogens also revealed more rapid and stronger protection against homotypic and heterotypic RVs' challenge than the monovalent RV immunogens. The results demonstrated that both the monovalent and multivalent RV immunogens exhibited high immunogenicity, but the monovalent RV immunogens could not provide enough neutralization antibodies to protect MA104 cells against the infection with heterotypic RV strains and timely protection against homotypic and heterotypic RVs, so the multivalent RV vaccine could not be replaced by the monovalent RV vaccine. |
| first_indexed | 2024-12-23T20:20:25Z |
| format | Article |
| id | doaj.art-4143b05806f84858b77f1f71309839de |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T20:20:25Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-4143b05806f84858b77f1f71309839de2022-12-21T17:32:33ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-01122e017215610.1371/journal.pone.0172156Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens.Kai MiXia OuLili GuoJing YeJinyuan WuShan YiXianglian NiuXiaoqin SunHongjun LiMaosheng SunThe strategies for developing rotavirus (RV) vaccines have always been controversial. At present, both the monovalent RV vaccine and the multivalent RV vaccine have displayed excellent safety and efficacy against RV infection and shown cross-reactive immunity, which laid the question whether the multivalent RV vaccine could be replaced by the monovalent RV vaccine. In this study, we focused on comparing the immunogenicity (serum neutralization activity and protection against homotypic and heterotypic RVs' challenge) of individual standard RV strains (monovalent RV immunogens) and different combinations of them (multivalent RV immunogens). In result, RV immunogens showed general immunogenicity and heterotypic reaction but the multivalent RV immunogens exhibited greater serum neutralization activity and stronger heterotypic reaction than the monovalent RV immunogens (P<0.05). As to the protection, the multivalent RV immunogens also revealed more rapid and stronger protection against homotypic and heterotypic RVs' challenge than the monovalent RV immunogens. The results demonstrated that both the monovalent and multivalent RV immunogens exhibited high immunogenicity, but the monovalent RV immunogens could not provide enough neutralization antibodies to protect MA104 cells against the infection with heterotypic RV strains and timely protection against homotypic and heterotypic RVs, so the multivalent RV vaccine could not be replaced by the monovalent RV vaccine.http://europepmc.org/articles/PMC5313208?pdf=render |
| spellingShingle | Kai Mi Xia Ou Lili Guo Jing Ye Jinyuan Wu Shan Yi Xianglian Niu Xiaoqin Sun Hongjun Li Maosheng Sun Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens. PLoS ONE |
| title | Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens. |
| title_full | Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens. |
| title_fullStr | Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens. |
| title_full_unstemmed | Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens. |
| title_short | Comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens. |
| title_sort | comparative analysis of the immunogenicity of monovalent and multivalent rotavirus immunogens |
| url | http://europepmc.org/articles/PMC5313208?pdf=render |
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