Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion
Abstract Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats. Methods: CIR was induced by the occlusion of l...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
2019-06-01
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| Series: | Acta Cirúrgica Brasileira |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000500204&tlng=en |
| _version_ | 1819106128294838272 |
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| author | Francisco Sandro Menezes-Rodrigues Paolo Ruggero Errante José Gustavo Padrão Tavares Renato Ribeiro Nogueira Ferraz Walter José Gomes Murched Omar Taha Carla Alessandra Scorza Fúlvio Alexandre Scorza Afonso Caricati-Neto |
| author_facet | Francisco Sandro Menezes-Rodrigues Paolo Ruggero Errante José Gustavo Padrão Tavares Renato Ribeiro Nogueira Ferraz Walter José Gomes Murched Omar Taha Carla Alessandra Scorza Fúlvio Alexandre Scorza Afonso Caricati-Neto |
| author_sort | Francisco Sandro Menezes-Rodrigues |
| collection | DOAJ |
| description | Abstract Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats. Methods: CIR was induced by the occlusion of left anterior descendent coronary artery (10 min) and reperfusion (75 min). The SHR was treated with β-AR antagonist atenolol (AT, 10 mg/kg, IV) 5 min before CIR, and NWR were treated with β-AR agonist isoproterenol (ISO, 0.5 mg/kg, IV) 5 min before CIR. Results: The treatment with AT increased the incidence of VA, AVB and LET in SHR, suggesting that spontaneous cardioprotection in hypertensive animals was abolished by blockade of β-AR. In contrast, the treatment with ISO significantly reduced the incidence of ventricular arrhythmia, atrioventricular blockade and lethality in NWR (30%, 20% and 20%, respectively), suggesting that the activation of β-AR stimulate cardioprotection in normotensive animals. Serum CK-MB were higher in SHR/CIR and NWR/CIR compared to respective SHAM group (not altered by treatment with AT or ISO). Conclusion: The pharmacological modulation of β-AR could be a new cardioprotective strategy for the therapy of myocardial dysfunctions induced by CIR related to cardiac surgery and cardiovascular diseases. |
| first_indexed | 2024-12-22T02:33:13Z |
| format | Article |
| id | doaj.art-414823f0fca54b96a667935ca48ac3e2 |
| institution | Directory Open Access Journal |
| issn | 0102-8650 |
| language | English |
| last_indexed | 2024-12-22T02:33:13Z |
| publishDate | 2019-06-01 |
| publisher | Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
| record_format | Article |
| series | Acta Cirúrgica Brasileira |
| spelling | doaj.art-414823f0fca54b96a667935ca48ac3e22022-12-21T18:41:50ZengSociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirúrgica Brasileira0102-86502019-06-0134510.1590/s0102-865020190050000005Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusionFrancisco Sandro Menezes-Rodrigueshttps://orcid.org/0000-0001-7913-0585Paolo Ruggero Errantehttps://orcid.org/0000-0002-6997-7587José Gustavo Padrão Tavareshttps://orcid.org/0000-0002-2931-1027Renato Ribeiro Nogueira Ferrazhttps://orcid.org/0000-0002-8931-895XWalter José Gomeshttps://orcid.org/0000-0003-3385-0215Murched Omar Tahahttps://orcid.org/0000-0001-7323-1393Carla Alessandra Scorzahttps://orcid.org/0000-0001-7810-4748Fúlvio Alexandre Scorzahttps://orcid.org/0000-0002-0694-8674Afonso Caricati-Netohttps://orcid.org/0000-0001-8615-4315Abstract Purpose: To evaluate the cardioprotective response of the pharmacological modulation of β-adrenergic receptors (β-AR) in animal model of cardiac ischemia and reperfusion (CIR), in spontaneously hypertensive (SHR) and normotensive (NWR) rats. Methods: CIR was induced by the occlusion of left anterior descendent coronary artery (10 min) and reperfusion (75 min). The SHR was treated with β-AR antagonist atenolol (AT, 10 mg/kg, IV) 5 min before CIR, and NWR were treated with β-AR agonist isoproterenol (ISO, 0.5 mg/kg, IV) 5 min before CIR. Results: The treatment with AT increased the incidence of VA, AVB and LET in SHR, suggesting that spontaneous cardioprotection in hypertensive animals was abolished by blockade of β-AR. In contrast, the treatment with ISO significantly reduced the incidence of ventricular arrhythmia, atrioventricular blockade and lethality in NWR (30%, 20% and 20%, respectively), suggesting that the activation of β-AR stimulate cardioprotection in normotensive animals. Serum CK-MB were higher in SHR/CIR and NWR/CIR compared to respective SHAM group (not altered by treatment with AT or ISO). Conclusion: The pharmacological modulation of β-AR could be a new cardioprotective strategy for the therapy of myocardial dysfunctions induced by CIR related to cardiac surgery and cardiovascular diseases.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000500204&tlng=enCardiovascular DiseasesMyocardial IschemiaReperfusionReceptors, AdrenergicDrug TherapyRats |
| spellingShingle | Francisco Sandro Menezes-Rodrigues Paolo Ruggero Errante José Gustavo Padrão Tavares Renato Ribeiro Nogueira Ferraz Walter José Gomes Murched Omar Taha Carla Alessandra Scorza Fúlvio Alexandre Scorza Afonso Caricati-Neto Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion Acta Cirúrgica Brasileira Cardiovascular Diseases Myocardial Ischemia Reperfusion Receptors, Adrenergic Drug Therapy Rats |
| title | Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion |
| title_full | Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion |
| title_fullStr | Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion |
| title_full_unstemmed | Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion |
| title_short | Pharmacological modulation of b-adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion |
| title_sort | pharmacological modulation of b adrenoceptors as a new cardioprotective strategy for therapy of myocardial dysfunction induced by ischemia and reperfusion |
| topic | Cardiovascular Diseases Myocardial Ischemia Reperfusion Receptors, Adrenergic Drug Therapy Rats |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502019000500204&tlng=en |
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