Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives
Peng Huang, Shaomi Zhu, Xin Liang, Qinxiu Zhang, Xiaohong Luo, Chi Liu, Linjiang Song Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of ChinaCorrespondence: Linjiang Song...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-07-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/regulatory-mechanisms-of-lncrnas-in-cancer-glycolysis-facts-and-perspe-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1818438704716316672 |
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| author | Huang P Zhu S Liang X Zhang Q Luo X Liu C Song L |
| author_facet | Huang P Zhu S Liang X Zhang Q Luo X Liu C Song L |
| author_sort | Huang P |
| collection | DOAJ |
| description | Peng Huang, Shaomi Zhu, Xin Liang, Qinxiu Zhang, Xiaohong Luo, Chi Liu, Linjiang Song Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of ChinaCorrespondence: Linjiang Song; Chi LiuReproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of ChinaEmail linjsong_scu@163.com; liuchi1985@163.comAbstract: Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer progression and therapeutic resistance and affect aerobic glycolysis via multiple mechanisms, including modulating glycolytic transporters and enzymes. Further, dysregulated signaling pathways are vital for glycolysis. In this review, we highlight regulatory mechanisms for lncRNAs in aerobic glycolysis that provide novel insights into cancer development. Moreover, a comprehensive understanding of the regulatory mechanisms of lncRNAs in aerobic glycolysis can provide new strategies for clinical cancer management.Keywords: lncRNA, cancer progression, glycolysis, signaling pathway |
| first_indexed | 2024-12-14T17:44:48Z |
| format | Article |
| id | doaj.art-414b6f8a898a4212bbe65ebf5155c122 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-14T17:44:48Z |
| publishDate | 2021-07-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-414b6f8a898a4212bbe65ebf5155c1222022-12-21T22:52:46ZengDove Medical PressCancer Management and Research1179-13222021-07-01Volume 135317533666596Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and PerspectivesHuang PZhu SLiang XZhang QLuo XLiu CSong LPeng Huang, Shaomi Zhu, Xin Liang, Qinxiu Zhang, Xiaohong Luo, Chi Liu, Linjiang Song Reproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of ChinaCorrespondence: Linjiang Song; Chi LiuReproductive & Women-Children Hospital, School of Medical and Life Sciences, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, 611137, People’s Republic of ChinaEmail linjsong_scu@163.com; liuchi1985@163.comAbstract: Cancer cells exhibit distinct metabolic characteristics that employ glycolysis to provide energy and intermediary metabolites. This aberrant metabolic phenotype favors cancer progression. LncRNAs are transcripts longer than 200 nucleotides that do not encode proteins. LncRNAs contribute to cancer progression and therapeutic resistance and affect aerobic glycolysis via multiple mechanisms, including modulating glycolytic transporters and enzymes. Further, dysregulated signaling pathways are vital for glycolysis. In this review, we highlight regulatory mechanisms for lncRNAs in aerobic glycolysis that provide novel insights into cancer development. Moreover, a comprehensive understanding of the regulatory mechanisms of lncRNAs in aerobic glycolysis can provide new strategies for clinical cancer management.Keywords: lncRNA, cancer progression, glycolysis, signaling pathwayhttps://www.dovepress.com/regulatory-mechanisms-of-lncrnas-in-cancer-glycolysis-facts-and-perspe-peer-reviewed-fulltext-article-CMARlncrnacancer progressionglycolysissignaling pathway |
| spellingShingle | Huang P Zhu S Liang X Zhang Q Luo X Liu C Song L Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives Cancer Management and Research lncrna cancer progression glycolysis signaling pathway |
| title | Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives |
| title_full | Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives |
| title_fullStr | Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives |
| title_full_unstemmed | Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives |
| title_short | Regulatory Mechanisms of LncRNAs in Cancer Glycolysis: Facts and Perspectives |
| title_sort | regulatory mechanisms of lncrnas in cancer glycolysis facts and perspectives |
| topic | lncrna cancer progression glycolysis signaling pathway |
| url | https://www.dovepress.com/regulatory-mechanisms-of-lncrnas-in-cancer-glycolysis-facts-and-perspe-peer-reviewed-fulltext-article-CMAR |
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