Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the path...
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| Format: | Article |
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MDPI AG
2023-03-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/3/828 |
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| author | Mohammad Sheikh-Ahmad Leonard Saiegh Anan Shalata Jacob Bejar Hila Kreizman-Shefer Majd F. Sirhan Ibrahim Matter Forat Swaid Monica Laniado Nama Mubariki Tova Rainis Ilana Rosenblatt Ekaterina Yovanovich Abed Agbarya |
| author_facet | Mohammad Sheikh-Ahmad Leonard Saiegh Anan Shalata Jacob Bejar Hila Kreizman-Shefer Majd F. Sirhan Ibrahim Matter Forat Swaid Monica Laniado Nama Mubariki Tova Rainis Ilana Rosenblatt Ekaterina Yovanovich Abed Agbarya |
| author_sort | Mohammad Sheikh-Ahmad |
| collection | DOAJ |
| description | Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11–288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21–67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; <i>p</i> = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; <i>p</i> = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease. |
| first_indexed | 2024-03-11T06:53:23Z |
| format | Article |
| id | doaj.art-414de2a066d040bf87ea0967491fa7a5 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T06:53:23Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-414de2a066d040bf87ea0967491fa7a52023-11-17T09:46:13ZengMDPI AGBiomedicines2227-90592023-03-0111382810.3390/biomedicines11030828Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center StudyMohammad Sheikh-Ahmad0Leonard Saiegh1Anan Shalata2Jacob Bejar3Hila Kreizman-Shefer4Majd F. Sirhan5Ibrahim Matter6Forat Swaid7Monica Laniado8Nama Mubariki9Tova Rainis10Ilana Rosenblatt11Ekaterina Yovanovich12Abed Agbarya13Institute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelInstitute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelInstitute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelDepartment of Pathology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelDepartment of Pathology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelDepartment of Pathology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelThe Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, IsraelThe Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, IsraelThe Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, IsraelDivision of Gastroenterology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelThe Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, IsraelInstitute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelInstitute of Endocrinology, Bnai Zion Medical Center, 47 Golomb St., Haifa 31048, IsraelThe Ruth and Bruce Rappaport Faculty of Medicine, Technion, Haifa 31096, IsraelType I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11–288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21–67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; <i>p</i> = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; <i>p</i> = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease.https://www.mdpi.com/2227-9059/11/3/828type I gastric neuroendocrine neoplasmmitotic countKi-67 indexchromogranin Agastrinrecurrence |
| spellingShingle | Mohammad Sheikh-Ahmad Leonard Saiegh Anan Shalata Jacob Bejar Hila Kreizman-Shefer Majd F. Sirhan Ibrahim Matter Forat Swaid Monica Laniado Nama Mubariki Tova Rainis Ilana Rosenblatt Ekaterina Yovanovich Abed Agbarya Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study Biomedicines type I gastric neuroendocrine neoplasm mitotic count Ki-67 index chromogranin A gastrin recurrence |
| title | Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study |
| title_full | Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study |
| title_fullStr | Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study |
| title_full_unstemmed | Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study |
| title_short | Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study |
| title_sort | factors predicting type i gastric neuroendocrine neoplasia recurrence a single center study |
| topic | type I gastric neuroendocrine neoplasm mitotic count Ki-67 index chromogranin A gastrin recurrence |
| url | https://www.mdpi.com/2227-9059/11/3/828 |
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