Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program
Purpose: The aims of this study were to introduce a new medical, pathway based on the concept of “enhanced recovery after surgery” (ERAS) for patients with metastatic epidural spinal cord compression (MESCC), and to test whether the ERAS program could improve clinical metrics among such patients.Met...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2023.1183913/full |
| _version_ | 1797828924197044224 |
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| author | Mingxing Lei Mingxing Lei Mingxing Lei Wenjing Zheng Wenjing Zheng Yuncen Cao Xuyong Cao Xiaolin Shi Xiuyun Su Yaosheng Liu Yaosheng Liu |
| author_facet | Mingxing Lei Mingxing Lei Mingxing Lei Wenjing Zheng Wenjing Zheng Yuncen Cao Xuyong Cao Xiaolin Shi Xiuyun Su Yaosheng Liu Yaosheng Liu |
| author_sort | Mingxing Lei |
| collection | DOAJ |
| description | Purpose: The aims of this study were to introduce a new medical, pathway based on the concept of “enhanced recovery after surgery” (ERAS) for patients with metastatic epidural spinal cord compression (MESCC), and to test whether the ERAS program could improve clinical metrics among such patients.Methods: Data from patients with MESCC (n = 98), collected between December 2016 and December 2019 (Non-ERAS cohort), and from 86 patients with metastatic epidural spinal cord compression collected between January 2020 and December 2022 (ERAS cohort), were retrospectively analyzed. Patients were treated by decompressive surgery combined with transpedicular screw implantation and internal fixation. Patient baseline clinical characteristics were collected and compared between the two cohorts. Surgical outcomes analyzed included operation time; intraoperative blood loss; postoperative length of hospital stay; time to ambulation, regular diet, urinary catheter removal, and radiation therapy; perioperative complications; anxiety; depression; and satisfaction with treatment.Results: No significant differences in clinical characteristics were found between the non-ERAS and enhanced recovery after surgery cohorts (all p > 0.050), indicating that the two cohorts were comparable. Regarding surgical outcomes, the enhanced recovery after surgery cohort had significantly less intraoperative blood loss (p < 0.001); shorter length of postoperative hospital stay (p < 0.001); shorter time to ambulation (p < 0.001), regular diet (p < 0.001), urinary catheter removal (p < 0.001), radiation administration (p < 0.001), and systemic internal therapy (p < 0.001); lower perioperative complication rate (p = 0.024); less postoperative anxiety (p = 0.041); and higher score for satisfaction with treatment (p < 0.001); whereas operation time (p = 0.524) and postoperative depression (p = 0.415) were similar between the two cohorts. Compliance analysis demonstrated that ERAS interventions were successfully conducted in the vast majority of patients.Conclusion: The enhanced recovery after surgery intervention is beneficial to patients with metastatic epidural spinal cord compression, according to data on intraoperative blood loss; length of hospital stay; time to ambulation, regular diet, urinary catheter removal, radiation exposure, and systemic internal therapy; perioperative complication; alleviation of anxiety; and improvement of satisfaction. However, clinical trials to investigate the effect of enhanced recovery after surgery are needed in the future. |
| first_indexed | 2024-04-09T13:12:12Z |
| format | Article |
| id | doaj.art-414e0dc39ea642da8e47c7f5490a9caf |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-09T13:12:12Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-414e0dc39ea642da8e47c7f5490a9caf2023-05-12T06:30:40ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2023-05-011110.3389/fcell.2023.11839131183913Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery programMingxing Lei0Mingxing Lei1Mingxing Lei2Wenjing Zheng3Wenjing Zheng4Yuncen Cao5Xuyong Cao6Xiaolin Shi7Xiuyun Su8Yaosheng Liu9Yaosheng Liu10Senior Department of Orthopedic Surgery, The Fourth Medical Center of PLA General Hospital, Beijing, ChinaChinese PLA Medical School, Beijing, ChinaHainan Hospital of PLA General Hospital, Beijing, ChinaDepartment of Chemical Poisoning Treatment, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Hematology, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Orthopedic Surgery, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Orthopedic Surgery, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaDepartment of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, ChinaIntelligent Medical Innovation institute, Southern University of Science and Technology Hospital, Shenzhen, ChinaDepartment of Orthopedic Surgery, The Fifth Medical Center of PLA General Hospital, Beijing, ChinaNational Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, PLA General Hospital, Beijing, ChinaPurpose: The aims of this study were to introduce a new medical, pathway based on the concept of “enhanced recovery after surgery” (ERAS) for patients with metastatic epidural spinal cord compression (MESCC), and to test whether the ERAS program could improve clinical metrics among such patients.Methods: Data from patients with MESCC (n = 98), collected between December 2016 and December 2019 (Non-ERAS cohort), and from 86 patients with metastatic epidural spinal cord compression collected between January 2020 and December 2022 (ERAS cohort), were retrospectively analyzed. Patients were treated by decompressive surgery combined with transpedicular screw implantation and internal fixation. Patient baseline clinical characteristics were collected and compared between the two cohorts. Surgical outcomes analyzed included operation time; intraoperative blood loss; postoperative length of hospital stay; time to ambulation, regular diet, urinary catheter removal, and radiation therapy; perioperative complications; anxiety; depression; and satisfaction with treatment.Results: No significant differences in clinical characteristics were found between the non-ERAS and enhanced recovery after surgery cohorts (all p > 0.050), indicating that the two cohorts were comparable. Regarding surgical outcomes, the enhanced recovery after surgery cohort had significantly less intraoperative blood loss (p < 0.001); shorter length of postoperative hospital stay (p < 0.001); shorter time to ambulation (p < 0.001), regular diet (p < 0.001), urinary catheter removal (p < 0.001), radiation administration (p < 0.001), and systemic internal therapy (p < 0.001); lower perioperative complication rate (p = 0.024); less postoperative anxiety (p = 0.041); and higher score for satisfaction with treatment (p < 0.001); whereas operation time (p = 0.524) and postoperative depression (p = 0.415) were similar between the two cohorts. Compliance analysis demonstrated that ERAS interventions were successfully conducted in the vast majority of patients.Conclusion: The enhanced recovery after surgery intervention is beneficial to patients with metastatic epidural spinal cord compression, according to data on intraoperative blood loss; length of hospital stay; time to ambulation, regular diet, urinary catheter removal, radiation exposure, and systemic internal therapy; perioperative complication; alleviation of anxiety; and improvement of satisfaction. However, clinical trials to investigate the effect of enhanced recovery after surgery are needed in the future.https://www.frontiersin.org/articles/10.3389/fcell.2023.1183913/fullmetastatic epidural spinal cord compressionenhanced recovery after surgerysurgical outcomemental healthspine metastases |
| spellingShingle | Mingxing Lei Mingxing Lei Mingxing Lei Wenjing Zheng Wenjing Zheng Yuncen Cao Xuyong Cao Xiaolin Shi Xiuyun Su Yaosheng Liu Yaosheng Liu Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program Frontiers in Cell and Developmental Biology metastatic epidural spinal cord compression enhanced recovery after surgery surgical outcome mental health spine metastases |
| title | Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program |
| title_full | Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program |
| title_fullStr | Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program |
| title_full_unstemmed | Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program |
| title_short | Treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program |
| title_sort | treatment of patients with metastatic epidural spinal cord compression using an enhanced recovery after surgery program |
| topic | metastatic epidural spinal cord compression enhanced recovery after surgery surgical outcome mental health spine metastases |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2023.1183913/full |
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