Validating a minipig model of reversible cerebral demyelination using human diagnostic modalities and electron microscopyResearch in context

Validating a minipig model of reversible cerebral demyelination using human diagnostic modalities and electron microscopyResearch in context

Summary: Background: Inflammatory demyelinating diseases of the central nervous system, such as multiple sclerosis, are significant sources of morbidity in young adults despite therapeutic advances. Current murine models of remyelination have limited applicability due to the low white matter conten...

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Main Authors: Mihai Ancău, Goutam Kumar Tanti, Vicki Marie Butenschoen, Jens Gempt, Igor Yakushev, Stephan Nekolla, Mark Mühlau, Christian Scheunemann, Sebastian Heininger, Benjamin Löwe, Erik Löwe, Silke Baer, Johannes Fischer, Judith Reiser, Sai S. Ayachit, Friederike Liesche-Starnecker, Jürgen Schlegel, Kaspar Matiasek, Martina Schifferer, Jan S. Kirschke, Thomas Misgeld, Tim Lueth, Bernhard Hemmer
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:EBioMedicine
Subjects:
In vivo minipig model
Lysophosphatidylcholine
Inflammatory-demyelinating brain disease
PET/MRI
Scanning electron microscopy
Electromagnetic-guided navigation system
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396424000173

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