Formulation and evaluation of mucoadhesive microspheres of metronidazole
Objective: Develop and evaluate mucoadhesive microspheres using Chitosan, Sodium alginate, and Sodium carboxymethyl cellulose (NaCMC) for sustained oral delivery of Metronidazole, aiming to improve bioavailability. Methods: Metronidazole-loaded microspheres were prepared via ionotropic gelation meth...
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| Format: | Article |
| Language: | English |
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Creative Pharma Assent
2024-02-01
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| Series: | Journal of Applied Pharmaceutical Research |
| Subjects: | |
| Online Access: | https://japtronline.com/index.php/joapr/article/view/388 |
| _version_ | 1797244472743952384 |
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| author | Dheeraj D. Chechare M. Siddaiah |
| author_facet | Dheeraj D. Chechare M. Siddaiah |
| author_sort | Dheeraj D. Chechare |
| collection | DOAJ |
| description | Objective: Develop and evaluate mucoadhesive microspheres using Chitosan, Sodium alginate, and Sodium carboxymethyl cellulose (NaCMC) for sustained oral delivery of Metronidazole, aiming to improve bioavailability. Methods: Metronidazole-loaded microspheres were prepared via ionotropic gelation method with varying polymer ratios. Particle size, entrapment efficiency, swelling index, mucoadhesion (sheep mucosae), morphology (SEM), in-vitro wash-off test, drug release profile, and stability (6 months) were evaluated. Results: Chitosan content positively correlated with microsphere size. Entrapment efficiency ranged from 51.43% to 94.15%. Chitosan-based formulations, especially MTZ-7 (Chitosan:NaCMC, 3:1), displayed the highest mucoadhesion. SEM analysis revealed rough, spherical microspheres with a continuous polymeric coat. In-vitro wash-off test demonstrated prolonged residence time for Chitosan formulations. Sustained drug release was observed throughout the study, with MTZ-7 exhibiting the most desirable release profile. Stability studies showed no significant changes in drug release for selected formulations after 6 months. Conclusions: Chitosan-based microspheres, particularly MTZ-7, demonstrated superior mucoadhesive properties, sustained and controlled drug release, and desirable stability. These findings suggest the potential of Chitosan-based microspheres as a promising oral drug delivery system for Metronidazole, potentially addressing bioavailability concerns and improving therapeutic efficacy. |
| first_indexed | 2024-04-24T19:11:33Z |
| format | Article |
| id | doaj.art-415312f031894952ac4c67240cc01efa |
| institution | Directory Open Access Journal |
| issn | 2348-0335 |
| language | English |
| last_indexed | 2024-04-24T19:11:33Z |
| publishDate | 2024-02-01 |
| publisher | Creative Pharma Assent |
| record_format | Article |
| series | Journal of Applied Pharmaceutical Research |
| spelling | doaj.art-415312f031894952ac4c67240cc01efa2024-03-26T09:28:02ZengCreative Pharma AssentJournal of Applied Pharmaceutical Research2348-03352024-02-01121939910.18231/j.joapr.2024.12.1.93.99389Formulation and evaluation of mucoadhesive microspheres of metronidazoleDheeraj D. Chechare0M. Siddaiah1Department of Pharmaceutical Sciences, Bhagwant University, RajasthanJawaharlal Nehru Technological University Anantapur, Anantapuram, Andhra PradeshObjective: Develop and evaluate mucoadhesive microspheres using Chitosan, Sodium alginate, and Sodium carboxymethyl cellulose (NaCMC) for sustained oral delivery of Metronidazole, aiming to improve bioavailability. Methods: Metronidazole-loaded microspheres were prepared via ionotropic gelation method with varying polymer ratios. Particle size, entrapment efficiency, swelling index, mucoadhesion (sheep mucosae), morphology (SEM), in-vitro wash-off test, drug release profile, and stability (6 months) were evaluated. Results: Chitosan content positively correlated with microsphere size. Entrapment efficiency ranged from 51.43% to 94.15%. Chitosan-based formulations, especially MTZ-7 (Chitosan:NaCMC, 3:1), displayed the highest mucoadhesion. SEM analysis revealed rough, spherical microspheres with a continuous polymeric coat. In-vitro wash-off test demonstrated prolonged residence time for Chitosan formulations. Sustained drug release was observed throughout the study, with MTZ-7 exhibiting the most desirable release profile. Stability studies showed no significant changes in drug release for selected formulations after 6 months. Conclusions: Chitosan-based microspheres, particularly MTZ-7, demonstrated superior mucoadhesive properties, sustained and controlled drug release, and desirable stability. These findings suggest the potential of Chitosan-based microspheres as a promising oral drug delivery system for Metronidazole, potentially addressing bioavailability concerns and improving therapeutic efficacy.https://japtronline.com/index.php/joapr/article/view/388metronidazolemucoadhesive microsphereschitosansodium alginatesodium carboxymethyl cellulosedrug delivery |
| spellingShingle | Dheeraj D. Chechare M. Siddaiah Formulation and evaluation of mucoadhesive microspheres of metronidazole Journal of Applied Pharmaceutical Research metronidazole mucoadhesive microspheres chitosan sodium alginate sodium carboxymethyl cellulose drug delivery |
| title | Formulation and evaluation of mucoadhesive microspheres of metronidazole |
| title_full | Formulation and evaluation of mucoadhesive microspheres of metronidazole |
| title_fullStr | Formulation and evaluation of mucoadhesive microspheres of metronidazole |
| title_full_unstemmed | Formulation and evaluation of mucoadhesive microspheres of metronidazole |
| title_short | Formulation and evaluation of mucoadhesive microspheres of metronidazole |
| title_sort | formulation and evaluation of mucoadhesive microspheres of metronidazole |
| topic | metronidazole mucoadhesive microspheres chitosan sodium alginate sodium carboxymethyl cellulose drug delivery |
| url | https://japtronline.com/index.php/joapr/article/view/388 |
| work_keys_str_mv | AT dheerajdchechare formulationandevaluationofmucoadhesivemicrospheresofmetronidazole AT msiddaiah formulationandevaluationofmucoadhesivemicrospheresofmetronidazole |