Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study
BackgroundWhether sarcopenic obesity had unfavorable effect on survival of peritoneal dialysis (PD) patients is unknown. We aimed to investigate the association between sarcopenic obesity and survival in PD patients.MethodsThis was a prospective observational study. Eligible PD patients from Novembe...
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| Format: | Article |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1342344/full |
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| author | Yiwei Shen Yiwei Shen Xinyu Su Xinyu Su Zanzhe Yu Zanzhe Yu Hao Yan Hao Yan Dahua Ma Yimei Xu Jiangzi Yuan Jiangzi Yuan Zhaohui Ni Zhaohui Ni Leyi Gu Leyi Gu Wei Fang Wei Fang |
| author_facet | Yiwei Shen Yiwei Shen Xinyu Su Xinyu Su Zanzhe Yu Zanzhe Yu Hao Yan Hao Yan Dahua Ma Yimei Xu Jiangzi Yuan Jiangzi Yuan Zhaohui Ni Zhaohui Ni Leyi Gu Leyi Gu Wei Fang Wei Fang |
| author_sort | Yiwei Shen |
| collection | DOAJ |
| description | BackgroundWhether sarcopenic obesity had unfavorable effect on survival of peritoneal dialysis (PD) patients is unknown. We aimed to investigate the association between sarcopenic obesity and survival in PD patients.MethodsThis was a prospective observational study. Eligible PD patients from November 2016 to December 2017 were enrolled and followed until August 31, 2023. Sarcopenia was defined following the recommendations of the Asian Working Group for Sarcopenia (AWGS) as low appendicular skeletal muscle mass index (ASMI) and handgrip strength (HGS). Obesity was defined using the percentage of body fat (PBF). Survival analysis was conducted using the Kaplan–Meier and log-rank test. The Cox regression and the cumulative incidence competing risk (CICR) analyzes were used to investigate the association between sarcopenic obesity and all-cause mortality.ResultsA total of 223 patients were enrolled with 133 (59.6%) males, a median age of 57.5 (44.6, 65.7) years, a median dialysis vintage of 20.3 (6.4, 57.7) months and 48 (21.5%) who had comorbid diabetes mellitus. Among them, 46 (20.6%) patients were sarcopenic, and 25 (11.2%) patients were diagnosed with sarcopenic obesity. After followed up for 51.6 (25.6, 73.9) months, the Kaplan–Meier curve showed the sarcopenic obesity (log-rank = 13.527, p < 0.001) group had significant lower survival rate compared to the nonsarcopenic non-obesity group. For multivariate analysis, the CICR method showed patients with sarcopenic obesity had significantly higher mortality rate (HR: 2.190, 95% CI: 1.011–4.743, p = 0.047) compared to those with nonsarcopenic non-obesity.ConclusionSarcopenia is not uncommon in PD patients, with a considerable proportion having sarcopenic obesity. There is a significant association between sarcopenic obesity and an increased risk of mortality in PD patients. |
| first_indexed | 2024-03-07T23:25:33Z |
| format | Article |
| id | doaj.art-4154984f1f984caf8f1a241a0e437c7d |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-03-07T23:25:33Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-4154984f1f984caf8f1a241a0e437c7d2024-02-21T04:25:52ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2024-02-011110.3389/fmed.2024.13423441342344Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort studyYiwei Shen0Yiwei Shen1Xinyu Su2Xinyu Su3Zanzhe Yu4Zanzhe Yu5Hao Yan6Hao Yan7Dahua Ma8Yimei Xu9Jiangzi Yuan10Jiangzi Yuan11Zhaohui Ni12Zhaohui Ni13Leyi Gu14Leyi Gu15Wei Fang16Wei Fang17Department of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaJiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, ChinaJiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaDepartment of Nephrology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, ChinaShanghai Center for Peritoneal Dialysis Research, Shanghai, ChinaBackgroundWhether sarcopenic obesity had unfavorable effect on survival of peritoneal dialysis (PD) patients is unknown. We aimed to investigate the association between sarcopenic obesity and survival in PD patients.MethodsThis was a prospective observational study. Eligible PD patients from November 2016 to December 2017 were enrolled and followed until August 31, 2023. Sarcopenia was defined following the recommendations of the Asian Working Group for Sarcopenia (AWGS) as low appendicular skeletal muscle mass index (ASMI) and handgrip strength (HGS). Obesity was defined using the percentage of body fat (PBF). Survival analysis was conducted using the Kaplan–Meier and log-rank test. The Cox regression and the cumulative incidence competing risk (CICR) analyzes were used to investigate the association between sarcopenic obesity and all-cause mortality.ResultsA total of 223 patients were enrolled with 133 (59.6%) males, a median age of 57.5 (44.6, 65.7) years, a median dialysis vintage of 20.3 (6.4, 57.7) months and 48 (21.5%) who had comorbid diabetes mellitus. Among them, 46 (20.6%) patients were sarcopenic, and 25 (11.2%) patients were diagnosed with sarcopenic obesity. After followed up for 51.6 (25.6, 73.9) months, the Kaplan–Meier curve showed the sarcopenic obesity (log-rank = 13.527, p < 0.001) group had significant lower survival rate compared to the nonsarcopenic non-obesity group. For multivariate analysis, the CICR method showed patients with sarcopenic obesity had significantly higher mortality rate (HR: 2.190, 95% CI: 1.011–4.743, p = 0.047) compared to those with nonsarcopenic non-obesity.ConclusionSarcopenia is not uncommon in PD patients, with a considerable proportion having sarcopenic obesity. There is a significant association between sarcopenic obesity and an increased risk of mortality in PD patients.https://www.frontiersin.org/articles/10.3389/fmed.2024.1342344/fullsarcopenic obesitysarcopeniaprevalencesurvivalperitoneal dialysis |
| spellingShingle | Yiwei Shen Yiwei Shen Xinyu Su Xinyu Su Zanzhe Yu Zanzhe Yu Hao Yan Hao Yan Dahua Ma Yimei Xu Jiangzi Yuan Jiangzi Yuan Zhaohui Ni Zhaohui Ni Leyi Gu Leyi Gu Wei Fang Wei Fang Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study Frontiers in Medicine sarcopenic obesity sarcopenia prevalence survival peritoneal dialysis |
| title | Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study |
| title_full | Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study |
| title_fullStr | Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study |
| title_full_unstemmed | Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study |
| title_short | Association between sarcopenic obesity and mortality in patients on peritoneal dialysis: a prospective cohort study |
| title_sort | association between sarcopenic obesity and mortality in patients on peritoneal dialysis a prospective cohort study |
| topic | sarcopenic obesity sarcopenia prevalence survival peritoneal dialysis |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1342344/full |
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