Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus Outbreaks
Neutralizing antibodies to Porcine Epidemic Diarrhea Virus (PEDV) can be detected by 3 weeks post-infection and remain detectable through at least 24 weeks post-infection. The objective of this study was to evaluate the levels of neutralizing antibodies in sow and piglet serum and sow milk to determ...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/16/3/324 |
| _version_ | 1797239085618692096 |
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| author | Justin Brown Kristin Skoland Heather Kittrell Josh Ellingson Paul Thomas Chelsea Ruston David Baum Locke Karriker |
| author_facet | Justin Brown Kristin Skoland Heather Kittrell Josh Ellingson Paul Thomas Chelsea Ruston David Baum Locke Karriker |
| author_sort | Justin Brown |
| collection | DOAJ |
| description | Neutralizing antibodies to Porcine Epidemic Diarrhea Virus (PEDV) can be detected by 3 weeks post-infection and remain detectable through at least 24 weeks post-infection. The objective of this study was to evaluate the levels of neutralizing antibodies in sow and piglet serum and sow milk to determine the duration of neutralizing antibodies following PEDV outbreaks. Two farms were selected for the study following outbreaks of PEDV. Monthly, cohorts of sows were sampled and followed through two farrowings. Following each farrowing, samples from piglets and milk were collected. Samples were evaluated for PEDV-neutralizing antibodies by a high-throughput fluorescent neutralization assay. Although neutralizing antibodies to PEDV can be detected throughout 15 months post-outbreak, a decrease in circulating neutralizing antibody levels is noted in farms beginning at six months post-outbreak. With decreasing levels, farms may become more vulnerable to PEDV outbreaks, and practitioners can focus on this time window to implement intervention strategies. |
| first_indexed | 2024-04-24T17:45:56Z |
| format | Article |
| id | doaj.art-41549d3fddb34f68b122ab0d535af7ca |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-04-24T17:45:56Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-41549d3fddb34f68b122ab0d535af7ca2024-03-27T14:07:33ZengMDPI AGViruses1999-49152024-02-0116332410.3390/v16030324Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus OutbreaksJustin Brown0Kristin Skoland1Heather Kittrell2Josh Ellingson3Paul Thomas4Chelsea Ruston5David Baum6Locke Karriker7Swine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USASwine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USASwine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USAAMVC Management Services, Audubon, IA 50025, USAAMVC Management Services, Audubon, IA 50025, USASwine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USADepartment of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USASwine Medicine Education Center, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USANeutralizing antibodies to Porcine Epidemic Diarrhea Virus (PEDV) can be detected by 3 weeks post-infection and remain detectable through at least 24 weeks post-infection. The objective of this study was to evaluate the levels of neutralizing antibodies in sow and piglet serum and sow milk to determine the duration of neutralizing antibodies following PEDV outbreaks. Two farms were selected for the study following outbreaks of PEDV. Monthly, cohorts of sows were sampled and followed through two farrowings. Following each farrowing, samples from piglets and milk were collected. Samples were evaluated for PEDV-neutralizing antibodies by a high-throughput fluorescent neutralization assay. Although neutralizing antibodies to PEDV can be detected throughout 15 months post-outbreak, a decrease in circulating neutralizing antibody levels is noted in farms beginning at six months post-outbreak. With decreasing levels, farms may become more vulnerable to PEDV outbreaks, and practitioners can focus on this time window to implement intervention strategies.https://www.mdpi.com/1999-4915/16/3/324porcine epidemic diarrhea virusneutralizing antibody |
| spellingShingle | Justin Brown Kristin Skoland Heather Kittrell Josh Ellingson Paul Thomas Chelsea Ruston David Baum Locke Karriker Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus Outbreaks Viruses porcine epidemic diarrhea virus neutralizing antibody |
| title | Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus Outbreaks |
| title_full | Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus Outbreaks |
| title_fullStr | Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus Outbreaks |
| title_full_unstemmed | Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus Outbreaks |
| title_short | Longitudinal and Cross-Sectional Evaluation of Two Commercial Swine Breeding Herds to Characterize Neutralizing Antibody Levels following Porcine Epidemic Diarrhea Virus Outbreaks |
| title_sort | longitudinal and cross sectional evaluation of two commercial swine breeding herds to characterize neutralizing antibody levels following porcine epidemic diarrhea virus outbreaks |
| topic | porcine epidemic diarrhea virus neutralizing antibody |
| url | https://www.mdpi.com/1999-4915/16/3/324 |
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