DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans
The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18089-1 |
| _version_ | 1818692355517054976 |
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| author | Kin Man Suen Fabian Braukmann Richard Butler Dalila Bensaddek Alper Akay Chi-Chuan Lin Dovilė Milonaitytė Neel Doshi Alexandra Sapetschnig Angus Lamond John Edward Ladbury Eric Alexander Miska |
| author_facet | Kin Man Suen Fabian Braukmann Richard Butler Dalila Bensaddek Alper Akay Chi-Chuan Lin Dovilė Milonaitytė Neel Doshi Alexandra Sapetschnig Angus Lamond John Edward Ladbury Eric Alexander Miska |
| author_sort | Kin Man Suen |
| collection | DOAJ |
| description | The C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo. |
| first_indexed | 2024-12-17T12:56:28Z |
| format | Article |
| id | doaj.art-41574a0478304ed5b2da4e86531e0f12 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T12:56:28Z |
| publishDate | 2020-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-41574a0478304ed5b2da4e86531e0f122022-12-21T21:47:28ZengNature PortfolioNature Communications2041-17232020-08-0111111310.1038/s41467-020-18089-1DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegansKin Man Suen0Fabian Braukmann1Richard Butler2Dalila Bensaddek3Alper Akay4Chi-Chuan Lin5Dovilė Milonaitytė6Neel Doshi7Alexandra Sapetschnig8Angus Lamond9John Edward Ladbury10Eric Alexander Miska11Wellcome Trust Cancer Research UK Gurdon Institute, University of CambridgeWellcome Trust Cancer Research UK Gurdon Institute, University of CambridgeWellcome Trust Cancer Research UK Gurdon Institute, University of CambridgeLaboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of DundeeWellcome Trust Cancer Research UK Gurdon Institute, University of CambridgeSchool of Molecular and Cellular Biology, University of Leeds, LC Miall BuildingSchool of Molecular and Cellular Biology, University of Leeds, LC Miall BuildingUniversity of Cambridge, School of Clinical Medicine, Cambridge Biomedical CampusWellcome Sanger Institute, Wellcome Trust Genome CampusLaboratory for Quantitative Proteomics, Centre for Gene Regulation and Expression, College of Life Sciences, University of DundeeSchool of Molecular and Cellular Biology, University of Leeds, LC Miall BuildingWellcome Trust Cancer Research UK Gurdon Institute, University of CambridgeThe C. elegans PIWI protein PRG-1 resides in the membraneless organelle P granule. Here, the authors identify the constitutive P granule protein DEPS-1 as an interactor of PRG-1 and show its function in piRNA-dependent silencing. DEPS-1 and PRG-1 form elongated condensates in vivo.https://doi.org/10.1038/s41467-020-18089-1 |
| spellingShingle | Kin Man Suen Fabian Braukmann Richard Butler Dalila Bensaddek Alper Akay Chi-Chuan Lin Dovilė Milonaitytė Neel Doshi Alexandra Sapetschnig Angus Lamond John Edward Ladbury Eric Alexander Miska DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans Nature Communications |
| title | DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans |
| title_full | DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans |
| title_fullStr | DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans |
| title_full_unstemmed | DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans |
| title_short | DEPS-1 is required for piRNA-dependent silencing and PIWI condensate organisation in Caenorhabditis elegans |
| title_sort | deps 1 is required for pirna dependent silencing and piwi condensate organisation in caenorhabditis elegans |
| url | https://doi.org/10.1038/s41467-020-18089-1 |
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