The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19
In the last 30 years the adipose cell has been object of several studies, turning its reputation from an inert cell into the main character involved in the pathophysiology of multiple diseases, including the ongoing COVID-19 pandemic, which has changed the clinical scenario of the last two years. Co...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/11/13/2109 |
| _version_ | 1797480465425235968 |
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| author | Francesca Cinti Saverio Cinti |
| author_facet | Francesca Cinti Saverio Cinti |
| author_sort | Francesca Cinti |
| collection | DOAJ |
| description | In the last 30 years the adipose cell has been object of several studies, turning its reputation from an inert cell into the main character involved in the pathophysiology of multiple diseases, including the ongoing COVID-19 pandemic, which has changed the clinical scenario of the last two years. Composed by two types of tissue (white and brown), with opposite roles, the adipose organ is now classified as a real endocrine organ whose dysfunction is involved in different diseases, mainly obesity and type 2 diabetes. In this mini-review we aim to retrace the adipose organ history from physiology to physiopathology, to provide therapeutic perspectives for the prevention and treatment of its two main related diseases (obesity and type 2 diabetes) and to summarize the most recent discoveries linking adipose tissue to COVID-19. |
| first_indexed | 2024-03-09T22:00:25Z |
| format | Article |
| id | doaj.art-4157cd19edd9452f8a8bd10bd7a5dd95 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T22:00:25Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4157cd19edd9452f8a8bd10bd7a5dd952023-11-23T19:49:41ZengMDPI AGCells2073-44092022-07-011113210910.3390/cells11132109The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19Francesca Cinti0Saverio Cinti1UOS Centro Malattie Endocrine e Metaboliche, UOC Endocrinologia e Diabetologia, Dipartimento di Scienze Mediche e Chirurgiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Roma, ItalyCenter of Obesity, Department of Experimental and Clinical Medicine, Marche Polytechnic University, 60126 Ancona, ItalyIn the last 30 years the adipose cell has been object of several studies, turning its reputation from an inert cell into the main character involved in the pathophysiology of multiple diseases, including the ongoing COVID-19 pandemic, which has changed the clinical scenario of the last two years. Composed by two types of tissue (white and brown), with opposite roles, the adipose organ is now classified as a real endocrine organ whose dysfunction is involved in different diseases, mainly obesity and type 2 diabetes. In this mini-review we aim to retrace the adipose organ history from physiology to physiopathology, to provide therapeutic perspectives for the prevention and treatment of its two main related diseases (obesity and type 2 diabetes) and to summarize the most recent discoveries linking adipose tissue to COVID-19.https://www.mdpi.com/2073-4409/11/13/2109adipocyteadipose organwhite adipose tissuebrown adipose tissuemammary glandtransdifferentiation |
| spellingShingle | Francesca Cinti Saverio Cinti The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19 Cells adipocyte adipose organ white adipose tissue brown adipose tissue mammary gland transdifferentiation |
| title | The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19 |
| title_full | The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19 |
| title_fullStr | The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19 |
| title_full_unstemmed | The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19 |
| title_short | The Endocrine Adipose Organ: A System Playing a Central Role in COVID-19 |
| title_sort | endocrine adipose organ a system playing a central role in covid 19 |
| topic | adipocyte adipose organ white adipose tissue brown adipose tissue mammary gland transdifferentiation |
| url | https://www.mdpi.com/2073-4409/11/13/2109 |
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