An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control Study
Background: Cystic ovarian disease (COD) is one of the common reproductive disorders which affecting the fertility of dairy cattle induces heavy financial burdens on herds owners. Various insecticides, fungicides and herbicides, collectively known as pesticides are frequently used in the agricultura...
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| Format: | Article |
| Language: | English |
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Shahid Beheshti University of Medical Sciences
2019-03-01
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| Series: | Novelty in Biomedicine |
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| Online Access: | http://journals.sbmu.ac.ir/nbm/article/view/22666 |
| _version_ | 1811274761571926016 |
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| author | Aida Sayad Mohammad Kazem Koohi Mehdi Vodjgani Khosrou Abdi Faramarz Gharagozloo Mohammad Amin Rezvanfar Hesameddin Akbarein Maryam Baeeri Mohammad Abdollahi |
| author_facet | Aida Sayad Mohammad Kazem Koohi Mehdi Vodjgani Khosrou Abdi Faramarz Gharagozloo Mohammad Amin Rezvanfar Hesameddin Akbarein Maryam Baeeri Mohammad Abdollahi |
| author_sort | Aida Sayad |
| collection | DOAJ |
| description | Background: Cystic ovarian disease (COD) is one of the common reproductive disorders which affecting the fertility of dairy cattle induces heavy financial burdens on herds owners. Various insecticides, fungicides and herbicides, collectively known as pesticides are frequently used in the agricultural systems of different countries. Given the fact that pesticides are known to have endocrine disrupting properties, exposure to these compounds may play a role in the development of COD.
Materials and Methods: The plasma concentrations of a complete profile of common pesticides including organophosphorus, organochlorine, and carbamate and pyrethroid compounds in the plasma of cattle with COD compared to healthy controls was examined. Moreover, plasma concentrations of inflammatory cytokines as well as oxidative stress parameters were investigated.
Results: No significant amounts of any of the pesticides investigated were detectable in the plasma of neither the healthy nor cystic cows. The plasma indices of total antioxidant capacity (TAC), thiol, lipid peroxidation (LPO), and reactive oxygen species (ROS) did not show any significant differences between the affected and the control groups. Tumor necrosis factors alpha (TNF-α), progesterone, lymphocyte, neutrophil, fibrinogen and MCHC had significantly higher amounts in the plasma of COD cows.
Conclusion: Findings of the present study do not support the notion that exposure to the studied pesticides is a contributing factor in the development of follicular cysts in dairy cattle. In addition, TNF-α might be affected as a factor in the pathogenesis of COD by an independent pathway of pesticides effect. |
| first_indexed | 2024-04-12T23:24:47Z |
| format | Article |
| id | doaj.art-4157e4edebe54ebc8354e9b720720450 |
| institution | Directory Open Access Journal |
| issn | 2345-3346 2345-3907 |
| language | English |
| last_indexed | 2024-04-12T23:24:47Z |
| publishDate | 2019-03-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Novelty in Biomedicine |
| spelling | doaj.art-4157e4edebe54ebc8354e9b7207204502022-12-22T03:12:26ZengShahid Beheshti University of Medical SciencesNovelty in Biomedicine2345-33462345-39072019-03-0172556310.22037/nbm.v7i2.2266611875An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control StudyAida Sayad0Mohammad Kazem Koohi1Mehdi Vodjgani2Khosrou Abdi3Faramarz Gharagozloo4Mohammad Amin Rezvanfar5Hesameddin Akbarein6Maryam Baeeri7Mohammad Abdollahi8Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Basic Sciences, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranDepartment of Radiopharmacy and Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranDepartment of Theriogenology, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranToxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IranDepartment of Epidemiology, Faculty of Veterinary Medicine, University of Tehran, Tehran, IranToxicology and Diseases Group, Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, IranToxicology and Diseases Group, The Institute of Pharmaceutical Sciences (TIPS), and Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, IranBackground: Cystic ovarian disease (COD) is one of the common reproductive disorders which affecting the fertility of dairy cattle induces heavy financial burdens on herds owners. Various insecticides, fungicides and herbicides, collectively known as pesticides are frequently used in the agricultural systems of different countries. Given the fact that pesticides are known to have endocrine disrupting properties, exposure to these compounds may play a role in the development of COD. Materials and Methods: The plasma concentrations of a complete profile of common pesticides including organophosphorus, organochlorine, and carbamate and pyrethroid compounds in the plasma of cattle with COD compared to healthy controls was examined. Moreover, plasma concentrations of inflammatory cytokines as well as oxidative stress parameters were investigated. Results: No significant amounts of any of the pesticides investigated were detectable in the plasma of neither the healthy nor cystic cows. The plasma indices of total antioxidant capacity (TAC), thiol, lipid peroxidation (LPO), and reactive oxygen species (ROS) did not show any significant differences between the affected and the control groups. Tumor necrosis factors alpha (TNF-α), progesterone, lymphocyte, neutrophil, fibrinogen and MCHC had significantly higher amounts in the plasma of COD cows. Conclusion: Findings of the present study do not support the notion that exposure to the studied pesticides is a contributing factor in the development of follicular cysts in dairy cattle. In addition, TNF-α might be affected as a factor in the pathogenesis of COD by an independent pathway of pesticides effect.http://journals.sbmu.ac.ir/nbm/article/view/22666pesticide, oxidative stress, tnf-α, bovine, cystic ovarian disease, reproductive toxicity, endocrine disruption |
| spellingShingle | Aida Sayad Mohammad Kazem Koohi Mehdi Vodjgani Khosrou Abdi Faramarz Gharagozloo Mohammad Amin Rezvanfar Hesameddin Akbarein Maryam Baeeri Mohammad Abdollahi An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control Study Novelty in Biomedicine pesticide, oxidative stress, tnf-α, bovine, cystic ovarian disease, reproductive toxicity, endocrine disruption |
| title | An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control Study |
| title_full | An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control Study |
| title_fullStr | An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control Study |
| title_full_unstemmed | An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control Study |
| title_short | An Evaluation of the Plasma Levels of Frequently Used Pesticides in Dairy Cattle and Its Possible Correlation with the Occurrence of Follicular Cystic Ovarian Disease: A Case-Control Study |
| title_sort | evaluation of the plasma levels of frequently used pesticides in dairy cattle and its possible correlation with the occurrence of follicular cystic ovarian disease a case control study |
| topic | pesticide, oxidative stress, tnf-α, bovine, cystic ovarian disease, reproductive toxicity, endocrine disruption |
| url | http://journals.sbmu.ac.ir/nbm/article/view/22666 |
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