Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits
This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Egyptian Society for Animal Management
2020-04-01
|
| Series: | Journal of Applied Veterinary Sciences |
| Subjects: | |
| Online Access: | https://javs.journals.ekb.eg/article_85584.html |
| _version_ | 1828924277474197504 |
|---|---|
| author | Omnia S. Farrag Doaa Salman Fatma Abo Zakaib Ali Arafat S. Sayed Motamed E. Mahmoud Abd-El Raheem A Abd-El Raheem |
| author_facet | Omnia S. Farrag Doaa Salman Fatma Abo Zakaib Ali Arafat S. Sayed Motamed E. Mahmoud Abd-El Raheem A Abd-El Raheem |
| author_sort | Omnia S. Farrag |
| collection | DOAJ |
| description | This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal saline. Group II, III, and IV were daily administrated with PTU in oral dosing of 50, 75, and 150 mg/kg, BWT, respectively, for three successive weeks. Serum T3 and T4 levels were measured in all groups. Increased serum creatinine and blood urea nitrogen levels (P<0.05) were also associated. Moreover, liver enzymes levels, aspartate aminotransferase, alanine aminotransferase, and total serum cholesterol levels showed a significant increase in a dose and time decedent manner. Thyroid glands of PTU-treated rabbits showed variable sized-follicles lined by multiple layers of follicular cells, which displayed signs of hyperactivity as the average follicular cell height. The diameter of its width was significantly increased compared with that in the control group. Besides, follicles were filled with a variable quantity of low-dense vacuolated colloids. Kidneys of such animals showed tubulointerstitial nephritis, glomerular atrophy, and multiple focal areas of mononuclear cell reaction. While the observed hepatic lesions were in the form of severe congestion in central vein and hepatic artery, hepatocellular necrosis, and granulocytic lymphoid cellular responses around portal areas associated with peri-portal fibrosis. Such lesions were dependent on doses of PTU. This study referred to that continuous treatment with an antithyroid drug PTU induced a hypothyroid state that was associated with impaired renal and hepatic functions in rabbits. |
| first_indexed | 2024-12-13T22:54:24Z |
| format | Article |
| id | doaj.art-415874cf892445eab7eb6562079c5b85 |
| institution | Directory Open Access Journal |
| issn | 1687-4072 2090-3308 |
| language | English |
| last_indexed | 2024-12-13T22:54:24Z |
| publishDate | 2020-04-01 |
| publisher | Egyptian Society for Animal Management |
| record_format | Article |
| series | Journal of Applied Veterinary Sciences |
| spelling | doaj.art-415874cf892445eab7eb6562079c5b852022-12-21T23:28:32ZengEgyptian Society for Animal ManagementJournal of Applied Veterinary Sciences1687-40722090-33082020-04-01524960https://dx.doi.org/10.21608/javs.2020.85584Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In RabbitsOmnia S. Farrag0Doaa Salman1Fatma Abo Zakaib Ali2Arafat S. Sayed3Motamed E. Mahmoud4https://orcid.org/0000-0003-0034-1043Abd-El Raheem A Abd-El Raheem5Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut; 71526, Egypt.Department of Animal Medicine, Faculty of Veterinary Medicine, Faculty of Veterinary Medicine, Sohag, University, Sohag, 82524, EgyptDepartment of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Sohag, University, Egypt.Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut; 71526, Egypt.Department of Animal Behavior and Husbandry, Faculty of Veterinary Medicine, Sohag, University, Egypt.Department of Animal Medicine, Faculty of Veterinary Medicine, Assiut University, Assiut; 71526, Egypt.This study was designed to investigate the effect of continuous treatment with the anti-thyroid drug, propylthiouracil (PTU), on renal and hepatic functions in rabbits as an experimental animal model. Animals were randomly divided into four different isolated groups (n = 10); Group I received normal saline. Group II, III, and IV were daily administrated with PTU in oral dosing of 50, 75, and 150 mg/kg, BWT, respectively, for three successive weeks. Serum T3 and T4 levels were measured in all groups. Increased serum creatinine and blood urea nitrogen levels (P<0.05) were also associated. Moreover, liver enzymes levels, aspartate aminotransferase, alanine aminotransferase, and total serum cholesterol levels showed a significant increase in a dose and time decedent manner. Thyroid glands of PTU-treated rabbits showed variable sized-follicles lined by multiple layers of follicular cells, which displayed signs of hyperactivity as the average follicular cell height. The diameter of its width was significantly increased compared with that in the control group. Besides, follicles were filled with a variable quantity of low-dense vacuolated colloids. Kidneys of such animals showed tubulointerstitial nephritis, glomerular atrophy, and multiple focal areas of mononuclear cell reaction. While the observed hepatic lesions were in the form of severe congestion in central vein and hepatic artery, hepatocellular necrosis, and granulocytic lymphoid cellular responses around portal areas associated with peri-portal fibrosis. Such lesions were dependent on doses of PTU. This study referred to that continuous treatment with an antithyroid drug PTU induced a hypothyroid state that was associated with impaired renal and hepatic functions in rabbits.https://javs.journals.ekb.eg/article_85584.htmlpropylthiouracilputrabbitsrenal dysfunction |
| spellingShingle | Omnia S. Farrag Doaa Salman Fatma Abo Zakaib Ali Arafat S. Sayed Motamed E. Mahmoud Abd-El Raheem A Abd-El Raheem Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits Journal of Applied Veterinary Sciences propylthiouracil put rabbits renal dysfunction |
| title | Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits |
| title_full | Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits |
| title_fullStr | Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits |
| title_full_unstemmed | Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits |
| title_short | Impact Of Continuous Treatment With Propylthiouracil On Renal And Hepatic Functions In Rabbits |
| title_sort | impact of continuous treatment with propylthiouracil on renal and hepatic functions in rabbits |
| topic | propylthiouracil put rabbits renal dysfunction |
| url | https://javs.journals.ekb.eg/article_85584.html |
| work_keys_str_mv | AT omniasfarrag impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT doaasalman impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT fatmaabozakaibali impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT arafatssayed impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT motamedemahmoud impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits AT abdelraheemaabdelraheem impactofcontinuoustreatmentwithpropylthiouracilonrenalandhepaticfunctionsinrabbits |