Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy
Immune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must overcome the metabolic limitations of the tumor microenvironment. Tumor metabolism has long been understood to be highly d...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/4/852 |
| _version_ | 1797571738776633344 |
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| author | Michael F. Coleman Alyssa J. Cozzo Alexander J. Pfeil Suhas K. Etigunta Stephen D. Hursting |
| author_facet | Michael F. Coleman Alyssa J. Cozzo Alexander J. Pfeil Suhas K. Etigunta Stephen D. Hursting |
| author_sort | Michael F. Coleman |
| collection | DOAJ |
| description | Immune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must overcome the metabolic limitations of the tumor microenvironment. Tumor metabolism has long been understood to be highly dysregulated, with potent immunosuppressive effects. Moreover, T cell activation and longevity within the tumor microenvironment are intimately tied to T cell metabolism and are required for the long-term efficacy of ICI therapy. We discuss in this review the intersection of metabolic competition in the tumor microenvironment, T cell activation and metabolism, the roles of tumor cell metabolism in immune evasion, and the impact of host metabolism in determining immune surveillance and ICI therapy outcomes. We also discussed the effects of obesity and calorie restriction—two important systemic metabolic perturbations that impact intrinsic metabolic pathways in T cells as well as cancer cells. |
| first_indexed | 2024-03-10T20:44:46Z |
| format | Article |
| id | doaj.art-415902353332456380c23379cea14553 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T20:44:46Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-415902353332456380c23379cea145532023-11-19T20:24:07ZengMDPI AGCancers2072-66942020-04-0112485210.3390/cancers12040852Cell Intrinsic and Systemic Metabolism in Tumor Immunity and ImmunotherapyMichael F. Coleman0Alyssa J. Cozzo1Alexander J. Pfeil2Suhas K. Etigunta3Stephen D. Hursting4Department of Nutrition, University of North Carolina, Chapel Hill, NC 27516, USADepartment of Nutrition, University of North Carolina, Chapel Hill, NC 27516, USADepartment of Nutrition, University of North Carolina, Chapel Hill, NC 27516, USADepartment of Nutrition, University of North Carolina, Chapel Hill, NC 27516, USADepartment of Nutrition, University of North Carolina, Chapel Hill, NC 27516, USAImmune checkpoint inhibitor (ICI) therapy has shown extraordinary promise at treating cancers otherwise resistant to treatment. However, for ICI therapy to be effective, it must overcome the metabolic limitations of the tumor microenvironment. Tumor metabolism has long been understood to be highly dysregulated, with potent immunosuppressive effects. Moreover, T cell activation and longevity within the tumor microenvironment are intimately tied to T cell metabolism and are required for the long-term efficacy of ICI therapy. We discuss in this review the intersection of metabolic competition in the tumor microenvironment, T cell activation and metabolism, the roles of tumor cell metabolism in immune evasion, and the impact of host metabolism in determining immune surveillance and ICI therapy outcomes. We also discussed the effects of obesity and calorie restriction—two important systemic metabolic perturbations that impact intrinsic metabolic pathways in T cells as well as cancer cells.https://www.mdpi.com/2072-6694/12/4/852immune checkpoint inhibitionmetabolismcancerobesitycalorie restriction |
| spellingShingle | Michael F. Coleman Alyssa J. Cozzo Alexander J. Pfeil Suhas K. Etigunta Stephen D. Hursting Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy Cancers immune checkpoint inhibition metabolism cancer obesity calorie restriction |
| title | Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy |
| title_full | Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy |
| title_fullStr | Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy |
| title_full_unstemmed | Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy |
| title_short | Cell Intrinsic and Systemic Metabolism in Tumor Immunity and Immunotherapy |
| title_sort | cell intrinsic and systemic metabolism in tumor immunity and immunotherapy |
| topic | immune checkpoint inhibition metabolism cancer obesity calorie restriction |
| url | https://www.mdpi.com/2072-6694/12/4/852 |
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