Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia
Objectives: The involvement of oxidative stress in the pathophysiology of preeclampsia (PE) has been already suggested. In this present study, we aimed to investigate the association of the genetic frequency of heme oxygense-1 (HMOX1) polymorphism with PE in Chinese Han women. Methods: We researched...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-02-01
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| Series: | Clinical and Experimental Hypertension |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/10641963.2019.1601202 |
| _version_ | 1797681286183124992 |
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| author | Xianping Lv Xueying Li Xueli Dai Mengchun Liu Cuijiao Wu Weiqing Song Jingli Wang Xiaoyan Ren Yan Cai |
| author_facet | Xianping Lv Xueying Li Xueli Dai Mengchun Liu Cuijiao Wu Weiqing Song Jingli Wang Xiaoyan Ren Yan Cai |
| author_sort | Xianping Lv |
| collection | DOAJ |
| description | Objectives: The involvement of oxidative stress in the pathophysiology of preeclampsia (PE) has been already suggested. In this present study, we aimed to investigate the association of the genetic frequency of heme oxygense-1 (HMOX1) polymorphism with PE in Chinese Han women. Methods: We researched the genetic distribution of rs2071746 polymorphism in HMOX1 by the TaqMan allelic discrimination real-time PCR between 1235 PE patients and 1720 healthy women. Results: We found there were′t significant differences in the distribution of HMOX1 rs2071746 polymorphism in PE compared to the control group (rs2071746, genotype χ2 = 0.282, P = 0.869 and allele χ2 = 0.027, P = 0.869, OR = 1.009, 95% = 0.909–1.120). Conclusion: The rs2071746 polymorphism in HMOX1 might not be related to PE in Chinese women, although further investigations should be conducted to confirm our findings. |
| first_indexed | 2024-03-11T23:42:46Z |
| format | Article |
| id | doaj.art-41598532e180497ca037629e3c67bd05 |
| institution | Directory Open Access Journal |
| issn | 1064-1963 1525-6006 |
| language | English |
| last_indexed | 2024-03-11T23:42:46Z |
| publishDate | 2020-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Clinical and Experimental Hypertension |
| spelling | doaj.art-41598532e180497ca037629e3c67bd052023-09-19T15:19:28ZengTaylor & Francis GroupClinical and Experimental Hypertension1064-19631525-60062020-02-0142216717010.1080/10641963.2019.16012021601202Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsiaXianping Lv0Xueying Li1Xueli Dai2Mengchun Liu3Cuijiao Wu4Weiqing Song5Jingli Wang6Xiaoyan Ren7Yan Cai8the First Affiliated Hospital of Zhengzhou UniversityBinzhou PolytechnicZibo Maternity and Child-care Hospitalthe Affiliated Hospital of Qingdao UniversityQingdao University Medical CollegeQingdao Municipal Hospital (Group)the Affiliated Hospital of Qingdao UniversityLiaocheng People‘s HospitalMaternity and Child Care of JinanObjectives: The involvement of oxidative stress in the pathophysiology of preeclampsia (PE) has been already suggested. In this present study, we aimed to investigate the association of the genetic frequency of heme oxygense-1 (HMOX1) polymorphism with PE in Chinese Han women. Methods: We researched the genetic distribution of rs2071746 polymorphism in HMOX1 by the TaqMan allelic discrimination real-time PCR between 1235 PE patients and 1720 healthy women. Results: We found there were′t significant differences in the distribution of HMOX1 rs2071746 polymorphism in PE compared to the control group (rs2071746, genotype χ2 = 0.282, P = 0.869 and allele χ2 = 0.027, P = 0.869, OR = 1.009, 95% = 0.909–1.120). Conclusion: The rs2071746 polymorphism in HMOX1 might not be related to PE in Chinese women, although further investigations should be conducted to confirm our findings.http://dx.doi.org/10.1080/10641963.2019.1601202hmox1pathogenesispolymorphismpreeclampsiaoxidative stress |
| spellingShingle | Xianping Lv Xueying Li Xueli Dai Mengchun Liu Cuijiao Wu Weiqing Song Jingli Wang Xiaoyan Ren Yan Cai Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia Clinical and Experimental Hypertension hmox1 pathogenesis polymorphism preeclampsia oxidative stress |
| title | Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia |
| title_full | Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia |
| title_fullStr | Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia |
| title_full_unstemmed | Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia |
| title_short | Investigation heme oxygenase-1 polymorphism with the pathogenesis of preeclampsia |
| title_sort | investigation heme oxygenase 1 polymorphism with the pathogenesis of preeclampsia |
| topic | hmox1 pathogenesis polymorphism preeclampsia oxidative stress |
| url | http://dx.doi.org/10.1080/10641963.2019.1601202 |
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