Olfactory Ensheathing Cells for Spinal Cord Injury
Olfactory ensheathing cells (OECs) are glia reported to sustain the continuous axon extension and successful topographic targeting of the olfactory receptor neurons responsible for the sense of smell (olfaction). Due to this distinctive property, OECs have been trialed in human cell transplant thera...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-06-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.1177/0963689718779353 |
| _version_ | 1818846986470686720 |
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| author | R. Yao M. Murtaza J. Tello Velasquez M. Todorovic A. Rayfield J. Ekberg M. Barton J. St John |
| author_facet | R. Yao M. Murtaza J. Tello Velasquez M. Todorovic A. Rayfield J. Ekberg M. Barton J. St John |
| author_sort | R. Yao |
| collection | DOAJ |
| description | Olfactory ensheathing cells (OECs) are glia reported to sustain the continuous axon extension and successful topographic targeting of the olfactory receptor neurons responsible for the sense of smell (olfaction). Due to this distinctive property, OECs have been trialed in human cell transplant therapies to assist in the repair of central nervous system injuries, particularly those of the spinal cord. Though many studies have reported neurological improvement, the therapy remains inconsistent and requires further improvement. Much of this variability stems from differing olfactory cell populations prior to transplantation into the injury site. While some studies have used purified cells, others have used unpurified transplants. Although both preparations have merits and faults, the latter increases the variability between transplants received by recipients. Without a robust purification procedure in OEC transplantation therapies, the full potential of OECs for spinal cord injury may not be realised. |
| first_indexed | 2024-12-19T05:54:16Z |
| format | Article |
| id | doaj.art-415b3ff06bdf4d29a09d03d8bca8151a |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-19T05:54:16Z |
| publishDate | 2018-06-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-415b3ff06bdf4d29a09d03d8bca8151a2022-12-21T20:33:30ZengSAGE PublishingCell Transplantation0963-68971555-38922018-06-012710.1177/0963689718779353Olfactory Ensheathing Cells for Spinal Cord InjuryR. Yao0M. Murtaza1J. Tello Velasquez2M. Todorovic3A. Rayfield4J. Ekberg5M. Barton6J. St John7 Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, Australia Menzies Health Institute Queensland, Griffith Health Centre, Griffith University, Gold Coast, Queensland, Australia Clem Jones Centre for Neurobiology and Stem Cell Research, Griffith Institute for Drug Discovery, Griffith University, Nathan, Brisbane, Queensland, Australia Menzies Health Institute Queensland, Griffith Health Centre, Griffith University, Gold Coast, Queensland, Australia Menzies Health Institute Queensland, Griffith Health Centre, Griffith University, Gold Coast, Queensland, Australia Menzies Health Institute Queensland, Griffith Health Centre, Griffith University, Gold Coast, Queensland, Australia Menzies Health Institute Queensland, Griffith Health Centre, Griffith University, Gold Coast, Queensland, Australia Menzies Health Institute Queensland, Griffith Health Centre, Griffith University, Gold Coast, Queensland, AustraliaOlfactory ensheathing cells (OECs) are glia reported to sustain the continuous axon extension and successful topographic targeting of the olfactory receptor neurons responsible for the sense of smell (olfaction). Due to this distinctive property, OECs have been trialed in human cell transplant therapies to assist in the repair of central nervous system injuries, particularly those of the spinal cord. Though many studies have reported neurological improvement, the therapy remains inconsistent and requires further improvement. Much of this variability stems from differing olfactory cell populations prior to transplantation into the injury site. While some studies have used purified cells, others have used unpurified transplants. Although both preparations have merits and faults, the latter increases the variability between transplants received by recipients. Without a robust purification procedure in OEC transplantation therapies, the full potential of OECs for spinal cord injury may not be realised.https://doi.org/10.1177/0963689718779353 |
| spellingShingle | R. Yao M. Murtaza J. Tello Velasquez M. Todorovic A. Rayfield J. Ekberg M. Barton J. St John Olfactory Ensheathing Cells for Spinal Cord Injury Cell Transplantation |
| title | Olfactory Ensheathing Cells for Spinal Cord Injury |
| title_full | Olfactory Ensheathing Cells for Spinal Cord Injury |
| title_fullStr | Olfactory Ensheathing Cells for Spinal Cord Injury |
| title_full_unstemmed | Olfactory Ensheathing Cells for Spinal Cord Injury |
| title_short | Olfactory Ensheathing Cells for Spinal Cord Injury |
| title_sort | olfactory ensheathing cells for spinal cord injury |
| url | https://doi.org/10.1177/0963689718779353 |
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