The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population
Abstract Objective The arachidonate 5-lipoxygenase (ALOX5) pathway has been investigated in diverse chronic inflammatory diseases including metabolic disorders. Recently, the ALOX5 polymorphism rs4987105 was identified to confer susceptibility to type 2 diabetes mellitus (T2DM), implicating its role...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2020-02-01
|
| Series: | BMC Research Notes |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13104-020-04953-2 |
| _version_ | 1818218998857203712 |
|---|---|
| author | Xi Li Jindi Su Shiguo Chen Sheng Lin Xiujie Zheng Baojiang Wang Keqin Yao Liping Lai Shan Duan |
| author_facet | Xi Li Jindi Su Shiguo Chen Sheng Lin Xiujie Zheng Baojiang Wang Keqin Yao Liping Lai Shan Duan |
| author_sort | Xi Li |
| collection | DOAJ |
| description | Abstract Objective The arachidonate 5-lipoxygenase (ALOX5) pathway has been investigated in diverse chronic inflammatory diseases including metabolic disorders. Recently, the ALOX5 polymorphism rs4987105 was identified to confer susceptibility to type 2 diabetes mellitus (T2DM), implicating its role in regulating glucose homeostasis. Gestational diabetes mellitus (GDM) shares similar pathogenic mechanism with T2DM. Thus, we aimed to evaluate the association between rs4987105 and gestational glucose metabolism in Chinese pregnant women. Results A total of 380 unrelated Chinese pregnant women including 241 GDM patients and 139 controls were included in this study. The genotypes of rs4987105 were examined by the Agena MassARRAY iPLEX platform, the association between rs4987105 and fasting plasma glucose (FPG) levels at 24–28 gestational weeks was evaluated using different statistical methods. We found that carriers of rs4987105 CT/TT genotypes exhibited significantly lower FPG levels (P = 0.011). In addition, we observed a significant association between rs4987105 and FPG levels after adjusting confounding variables in the linear regression analysis using dominant genetic model (b = − 0.218; P = 0.01). The present study for the first time reported that the rs4987105 of 5-lipoxygenase (ALOX5) gene was associated with gestational glucose metabolism in Chinese pregnant women. |
| first_indexed | 2024-12-12T07:32:40Z |
| format | Article |
| id | doaj.art-415bf018f15e4892a99442ee764ba551 |
| institution | Directory Open Access Journal |
| issn | 1756-0500 |
| language | English |
| last_indexed | 2024-12-12T07:32:40Z |
| publishDate | 2020-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Research Notes |
| spelling | doaj.art-415bf018f15e4892a99442ee764ba5512022-12-22T00:32:58ZengBMCBMC Research Notes1756-05002020-02-011311510.1186/s13104-020-04953-2The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese populationXi Li0Jindi Su1Shiguo Chen2Sheng Lin3Xiujie Zheng4Baojiang Wang5Keqin Yao6Liping Lai7Shan Duan8Laboratory of Medical Genetics, Shenzhen Health Development Research CenterLaboratory of Medical Genetics, Shenzhen Health Development Research CenterLaboratory of Medical Genetics, Shenzhen Health Development Research CenterLaboratory of Medical Genetics, Shenzhen Health Development Research CenterLaboratory of Medical Genetics, Shenzhen Health Development Research CenterLaboratory of Medical Genetics, Shenzhen Health Development Research CenterLaboratory of Medical Genetics, Shenzhen Health Development Research CenterEndocrine Department, Futian Center for Chronic Disease ControlLaboratory of Medical Genetics, Shenzhen Health Development Research CenterAbstract Objective The arachidonate 5-lipoxygenase (ALOX5) pathway has been investigated in diverse chronic inflammatory diseases including metabolic disorders. Recently, the ALOX5 polymorphism rs4987105 was identified to confer susceptibility to type 2 diabetes mellitus (T2DM), implicating its role in regulating glucose homeostasis. Gestational diabetes mellitus (GDM) shares similar pathogenic mechanism with T2DM. Thus, we aimed to evaluate the association between rs4987105 and gestational glucose metabolism in Chinese pregnant women. Results A total of 380 unrelated Chinese pregnant women including 241 GDM patients and 139 controls were included in this study. The genotypes of rs4987105 were examined by the Agena MassARRAY iPLEX platform, the association between rs4987105 and fasting plasma glucose (FPG) levels at 24–28 gestational weeks was evaluated using different statistical methods. We found that carriers of rs4987105 CT/TT genotypes exhibited significantly lower FPG levels (P = 0.011). In addition, we observed a significant association between rs4987105 and FPG levels after adjusting confounding variables in the linear regression analysis using dominant genetic model (b = − 0.218; P = 0.01). The present study for the first time reported that the rs4987105 of 5-lipoxygenase (ALOX5) gene was associated with gestational glucose metabolism in Chinese pregnant women.http://link.springer.com/article/10.1186/s13104-020-04953-2Gestational diabetes mellitusGenetic susceptibilityALOX5PolymorphismFasting plasma glucose |
| spellingShingle | Xi Li Jindi Su Shiguo Chen Sheng Lin Xiujie Zheng Baojiang Wang Keqin Yao Liping Lai Shan Duan The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population BMC Research Notes Gestational diabetes mellitus Genetic susceptibility ALOX5 Polymorphism Fasting plasma glucose |
| title | The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population |
| title_full | The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population |
| title_fullStr | The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population |
| title_full_unstemmed | The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population |
| title_short | The association between the rs4987105 of 5-lipoxygenase (ALOX5) gene and gestational glucose metabolism in Chinese population |
| title_sort | association between the rs4987105 of 5 lipoxygenase alox5 gene and gestational glucose metabolism in chinese population |
| topic | Gestational diabetes mellitus Genetic susceptibility ALOX5 Polymorphism Fasting plasma glucose |
| url | http://link.springer.com/article/10.1186/s13104-020-04953-2 |
| work_keys_str_mv | AT xili theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT jindisu theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT shiguochen theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT shenglin theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT xiujiezheng theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT baojiangwang theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT keqinyao theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT lipinglai theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT shanduan theassociationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT xili associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT jindisu associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT shiguochen associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT shenglin associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT xiujiezheng associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT baojiangwang associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT keqinyao associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT lipinglai associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation AT shanduan associationbetweenthers4987105of5lipoxygenasealox5geneandgestationalglucosemetabolisminchinesepopulation |