Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats
<p>Abstract</p> <p>Background</p> <p>The leaves and root of <it>Flabellaria paniculata</it> (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic...
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BMC
2012-10-01
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| Series: | BMC Complementary and Alternative Medicine |
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| Online Access: | http://www.biomedcentral.com/1472-6882/12/168 |
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| author | Sofidiya Margaret O Agufobi Lilian Akindele Abidemi J Olowe Johnson A Familoni Oluwole B |
| author_facet | Sofidiya Margaret O Agufobi Lilian Akindele Abidemi J Olowe Johnson A Familoni Oluwole B |
| author_sort | Sofidiya Margaret O |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>The leaves and root of <it>Flabellaria paniculata</it> (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic extracts from the leaves (FPL) and root (FPR) of <it>F. paniculata</it> on gastric ulcers in rats.</p> <p>Methods</p> <p>The effect of FPL and FPR (100, 200 and 400 mg/kg) was evaluated in ethanol and indomethacin gastric ulcer models. Control groups for FPL and FPR were orally treated with 3% Tween 20 and distilled water respectively. FPL was further investigated in pylorus ligation model. Misoprostol and cimetidine were used as reference.</p> <p>Results</p> <p>FPL significantly (P < 0.05) reduced gastric lesions by 82.22% and 67.32% in ethanol and indomethacin induced ulcer models at 100 mg/kg respectively while FPR (100, 200 and 400 mg/kg) did not exert significant effect in the two models. In pylorus ligation model, FPL exerted a significant preventive antiulcer effect as indicated by reduction in gastric volume at 200 and 400 mg/kg doses. Only 400 mg/kg of the extract exerted a significant reduction in ulcer index when compared with the control group. The oral route LD<sub>50</sub> of FPL was estimated to be 4570 mg/kg while that of FPR was 2754 mg/kg. The LD<sub>50</sub> in intraperitoneal injection was estimated to be 1202.26 and 1380.38 mg/kg for FPL and FPR respectively. The phytochemical investigation showed that both extracts possess triterpenoids and saponin, while the presence of flavonoid was detected only in FPL.</p> <p>Conclusions</p> <p>The results of this study indicated that FPL and not FPR is effective against experimentally induced gastric ulcers. The presence of varied phytochemical constituents probably influenced the pharmacological differences between the two extracts.</p> |
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| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-10T08:04:01Z |
| publishDate | 2012-10-01 |
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| spelling | doaj.art-415d5b10714b42ffad7fbcce013c220a2022-12-22T01:56:43ZengBMCBMC Complementary and Alternative Medicine1472-68822012-10-0112116810.1186/1472-6882-12-168Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in ratsSofidiya Margaret OAgufobi LilianAkindele Abidemi JOlowe Johnson AFamiloni Oluwole B<p>Abstract</p> <p>Background</p> <p>The leaves and root of <it>Flabellaria paniculata</it> (Malpighiaceae) are frequently used in the treatment of wounds and ulcers in Nigerian folk medicine. The purpose of this study was to compare the effect of ethanolic extracts from the leaves (FPL) and root (FPR) of <it>F. paniculata</it> on gastric ulcers in rats.</p> <p>Methods</p> <p>The effect of FPL and FPR (100, 200 and 400 mg/kg) was evaluated in ethanol and indomethacin gastric ulcer models. Control groups for FPL and FPR were orally treated with 3% Tween 20 and distilled water respectively. FPL was further investigated in pylorus ligation model. Misoprostol and cimetidine were used as reference.</p> <p>Results</p> <p>FPL significantly (P < 0.05) reduced gastric lesions by 82.22% and 67.32% in ethanol and indomethacin induced ulcer models at 100 mg/kg respectively while FPR (100, 200 and 400 mg/kg) did not exert significant effect in the two models. In pylorus ligation model, FPL exerted a significant preventive antiulcer effect as indicated by reduction in gastric volume at 200 and 400 mg/kg doses. Only 400 mg/kg of the extract exerted a significant reduction in ulcer index when compared with the control group. The oral route LD<sub>50</sub> of FPL was estimated to be 4570 mg/kg while that of FPR was 2754 mg/kg. The LD<sub>50</sub> in intraperitoneal injection was estimated to be 1202.26 and 1380.38 mg/kg for FPL and FPR respectively. The phytochemical investigation showed that both extracts possess triterpenoids and saponin, while the presence of flavonoid was detected only in FPL.</p> <p>Conclusions</p> <p>The results of this study indicated that FPL and not FPR is effective against experimentally induced gastric ulcers. The presence of varied phytochemical constituents probably influenced the pharmacological differences between the two extracts.</p>http://www.biomedcentral.com/1472-6882/12/168<it>Flabellaria paniculata</it> CavMalphighiaceaeAntiulcerEthanol-induced ulcerIndomethacin-induced ulcerPylorus ligation-induced ulcerAcute toxicity |
| spellingShingle | Sofidiya Margaret O Agufobi Lilian Akindele Abidemi J Olowe Johnson A Familoni Oluwole B Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats BMC Complementary and Alternative Medicine <it>Flabellaria paniculata</it> Cav Malphighiaceae Antiulcer Ethanol-induced ulcer Indomethacin-induced ulcer Pylorus ligation-induced ulcer Acute toxicity |
| title | Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats |
| title_full | Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats |
| title_fullStr | Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats |
| title_full_unstemmed | Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats |
| title_short | Effect of <it>Flabellaria paniculata</it> Cav. extracts on gastric ulcer in rats |
| title_sort | effect of it flabellaria paniculata it cav extracts on gastric ulcer in rats |
| topic | <it>Flabellaria paniculata</it> Cav Malphighiaceae Antiulcer Ethanol-induced ulcer Indomethacin-induced ulcer Pylorus ligation-induced ulcer Acute toxicity |
| url | http://www.biomedcentral.com/1472-6882/12/168 |
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