The MHC-II Transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators

The MHC-II Transactivator CIITA, a restriction factor against oncogenic HTLV-1 and HTLV-2 retroviruses: similarities and differences in the inhibition of Tax-1 and Tax-2 viral transactivators

The activation of CD4+ T helper cells is strictly dependent on the presentation of antigenic peptides by MHC Class II molecules. MHC-II expression is primarily regulated at the transcriptional level by the AIR-1 gene product CIITA (Class II transactivator). Thus, CIITA plays a pivotal role in the tr...

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Bibliographic Details
Main Authors: Greta eForlani, Rawan eAbdallah, Roberto S Accolla, Giovanna eTosi
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-08-01
Series:Frontiers in Microbiology
Subjects:
CIITA
restriction factors
viral replication
HTLV-1 Tax-1
HTLV-2 Tax-2
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2013.00234/full

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