Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system

Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system

The aim of this work was to evaluate the compatibility between dipyrone, caffeine and orphenadrine citrate, active pharmaceutical ingredients (APIs) commonly used in fixed-dose combination (FDC) in analgesic medicines. The APIs were analyzed by Differential Scanning Calorimetry (DSC), Differential T...

Full description

Bibliographic Details
Main Authors: Laianne Carla B. Alencar, Cleildo P. Santana, Karla Monik A. Silva, Fernanda P. Nóbrega, Lidiane P. Correia, Widson M. Santos, Fabrício Havy D. Andrade, Fábio S. Santos, Rui Oliveira Macêdo, Ana Cláudia D. Medeiros
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Chemical Thermodynamics and Thermal Analysis
Subjects:
Polymorphism
DSC photovisual
Compatibility study
Online Access:http://www.sciencedirect.com/science/article/pii/S2667312622000384
Description
Summary:The aim of this work was to evaluate the compatibility between dipyrone, caffeine and orphenadrine citrate, active pharmaceutical ingredients (APIs) commonly used in fixed-dose combination (FDC) in analgesic medicines. The APIs were analyzed by Differential Scanning Calorimetry (DSC), Differential Thermal Analysis (DTA), Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Powder Diffraction (XRPD). DSC evaluated the heat and temperature of thermal events of APIs. Physical binary and ternary mixtures in the mass ratio of 1:1 and 1:1:1 were analyzed by DTA and showed only overlap of the peaks. DSC photovisual showed various phase transition processes with complete decomposition. FTIR and XRPD of binary and ternary mixtures showed no change in the profiles of APIs and the study showed that the APIs can be inserted in the same formulation.
ISSN:2667-3126

Similar Items