Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system
The aim of this work was to evaluate the compatibility between dipyrone, caffeine and orphenadrine citrate, active pharmaceutical ingredients (APIs) commonly used in fixed-dose combination (FDC) in analgesic medicines. The APIs were analyzed by Differential Scanning Calorimetry (DSC), Differential T...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-08-01
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| Series: | Chemical Thermodynamics and Thermal Analysis |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667312622000384 |
| _version_ | 1811281281935212544 |
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| author | Laianne Carla B. Alencar Cleildo P. Santana Karla Monik A. Silva Fernanda P. Nóbrega Lidiane P. Correia Widson M. Santos Fabrício Havy D. Andrade Fábio S. Santos Rui Oliveira Macêdo Ana Cláudia D. Medeiros |
| author_facet | Laianne Carla B. Alencar Cleildo P. Santana Karla Monik A. Silva Fernanda P. Nóbrega Lidiane P. Correia Widson M. Santos Fabrício Havy D. Andrade Fábio S. Santos Rui Oliveira Macêdo Ana Cláudia D. Medeiros |
| author_sort | Laianne Carla B. Alencar |
| collection | DOAJ |
| description | The aim of this work was to evaluate the compatibility between dipyrone, caffeine and orphenadrine citrate, active pharmaceutical ingredients (APIs) commonly used in fixed-dose combination (FDC) in analgesic medicines. The APIs were analyzed by Differential Scanning Calorimetry (DSC), Differential Thermal Analysis (DTA), Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Powder Diffraction (XRPD). DSC evaluated the heat and temperature of thermal events of APIs. Physical binary and ternary mixtures in the mass ratio of 1:1 and 1:1:1 were analyzed by DTA and showed only overlap of the peaks. DSC photovisual showed various phase transition processes with complete decomposition. FTIR and XRPD of binary and ternary mixtures showed no change in the profiles of APIs and the study showed that the APIs can be inserted in the same formulation. |
| first_indexed | 2024-04-13T01:29:46Z |
| format | Article |
| id | doaj.art-4160dd3705294d1288d85f2fb1b0736d |
| institution | Directory Open Access Journal |
| issn | 2667-3126 |
| language | English |
| last_indexed | 2024-04-13T01:29:46Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Chemical Thermodynamics and Thermal Analysis |
| spelling | doaj.art-4160dd3705294d1288d85f2fb1b0736d2022-12-22T03:08:32ZengElsevierChemical Thermodynamics and Thermal Analysis2667-31262022-08-017100072Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual systemLaianne Carla B. Alencar0Cleildo P. Santana1Karla Monik A. Silva2Fernanda P. Nóbrega3Lidiane P. Correia4Widson M. Santos5Fabrício Havy D. Andrade6Fábio S. Santos7Rui Oliveira Macêdo8Ana Cláudia D. Medeiros9Universidade Estadual da Paraíba, Laboratório de Desenvolvimento e Ensaios em Medicamentos, Campina Grande, PB, BrasilCentro de Tecnologia em Desenvolvimento de Medicamentos, Faculdade de Farmácia, Universidade Federal de Minas Gerais, Belo Horizonte, MG, BrazilFaculdade Maurício de Nassau, Campina Grande, PB, BrasilUniversidade Estadual da Paraíba, Laboratório de Desenvolvimento e Ensaios em Medicamentos, Campina Grande, PB, BrasilUniversidade Estadual da Paraíba, Laboratório CERTBIO, Campina Grande, PB, BrasilUniversidade Estadual da Paraíba, Laboratório de Desenvolvimento e Ensaios em Medicamentos, Campina Grande, PB, BrasilUniversidade Federal da Paraíba, Laboratórios Unificados de Desenvolvimento Farmacêutico e Ensaios, João Pessoa, PB, BrasilUniversidade Federal da Paraíba, Laboratórios Unificados de Desenvolvimento Farmacêutico e Ensaios, João Pessoa, PB, BrasilUniversidade Federal da Paraíba, Laboratórios Unificados de Desenvolvimento Farmacêutico e Ensaios, João Pessoa, PB, BrasilUniversidade Estadual da Paraíba, Laboratório de Desenvolvimento e Ensaios em Medicamentos, Campina Grande, PB, Brasil; Corresponding author.The aim of this work was to evaluate the compatibility between dipyrone, caffeine and orphenadrine citrate, active pharmaceutical ingredients (APIs) commonly used in fixed-dose combination (FDC) in analgesic medicines. The APIs were analyzed by Differential Scanning Calorimetry (DSC), Differential Thermal Analysis (DTA), Fourier Transform Infrared Spectroscopy (FTIR) and X-Ray Powder Diffraction (XRPD). DSC evaluated the heat and temperature of thermal events of APIs. Physical binary and ternary mixtures in the mass ratio of 1:1 and 1:1:1 were analyzed by DTA and showed only overlap of the peaks. DSC photovisual showed various phase transition processes with complete decomposition. FTIR and XRPD of binary and ternary mixtures showed no change in the profiles of APIs and the study showed that the APIs can be inserted in the same formulation.http://www.sciencedirect.com/science/article/pii/S2667312622000384PolymorphismDSC photovisualCompatibility study |
| spellingShingle | Laianne Carla B. Alencar Cleildo P. Santana Karla Monik A. Silva Fernanda P. Nóbrega Lidiane P. Correia Widson M. Santos Fabrício Havy D. Andrade Fábio S. Santos Rui Oliveira Macêdo Ana Cláudia D. Medeiros Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system Chemical Thermodynamics and Thermal Analysis Polymorphism DSC photovisual Compatibility study |
| title | Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system |
| title_full | Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system |
| title_fullStr | Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system |
| title_full_unstemmed | Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system |
| title_short | Thermal study of active pharmaceutical ingredients used as analgesics by DTA and DSC coupled to photovisual system |
| title_sort | thermal study of active pharmaceutical ingredients used as analgesics by dta and dsc coupled to photovisual system |
| topic | Polymorphism DSC photovisual Compatibility study |
| url | http://www.sciencedirect.com/science/article/pii/S2667312622000384 |
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