COUP-TFII in Health and Disease
The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins acting as ligand-activated transcription factors. Functionally, NRs are essential in embryogenesis and organogenesis and in adulthood they are involved in almost every physiological and pathological process. Our k...
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| Format: | Article |
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MDPI AG
2019-12-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/1/101 |
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| author | Simone Polvani Sara Pepe Stefano Milani Andrea Galli |
| author_facet | Simone Polvani Sara Pepe Stefano Milani Andrea Galli |
| author_sort | Simone Polvani |
| collection | DOAJ |
| description | The nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins acting as ligand-activated transcription factors. Functionally, NRs are essential in embryogenesis and organogenesis and in adulthood they are involved in almost every physiological and pathological process. Our knowledge of NRs action has greatly improved in recent years, demonstrating that both their expression and activity are tightly regulated by a network of signaling pathways, miRNA and reciprocal interactions. The Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII, NR2F2) is a NR classified as an orphan due to the lack of a known natural ligand. Although its expression peaks during development, and then decreases considerably, in adult tissues, COUP-TFII is an important regulator of differentiation and it is variably implicated in tissues homeostasis. As such, alterations of its expression or its transcriptional activity have been studied and linked to a spectrum of diseases in organs and tissues of different origins. Indeed, an altered COUP-TFII expression and activity may cause infertility, abnormality in the vascular system and metabolic diseases like diabetes. Moreover, COUP-TFII is actively investigated in cancer research but its role in tumor progression is yet to be fully understood. In this review, we summarize the current understanding of COUP-TFII in healthy and pathological conditions, proposing an updated and critical view of the many functions of this NR. |
| first_indexed | 2024-03-12T06:13:34Z |
| format | Article |
| id | doaj.art-4160e19d7e4140e290fcd06ca039f2eb |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-12T06:13:34Z |
| publishDate | 2019-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-4160e19d7e4140e290fcd06ca039f2eb2023-09-03T02:48:37ZengMDPI AGCells2073-44092019-12-019110110.3390/cells9010101cells9010101COUP-TFII in Health and DiseaseSimone Polvani0Sara Pepe1Stefano Milani2Andrea Galli3Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Gastroenterology Unit, University of Florence, viale Pieraccini 6, 50139 Firenze, ItalyIstituto per la Ricerca, la Prevenzione e la rete Oncologica (ISPRO), viale Pieraccini 6, 50139 Firenze, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, Gastroenterology Unit, University of Florence, viale Pieraccini 6, 50139 Firenze, ItalyDepartment of Experimental and Clinical Biomedical Sciences “Mario Serio”, Gastroenterology Unit, University of Florence, viale Pieraccini 6, 50139 Firenze, ItalyThe nuclear receptors (NRs) belong to a vast family of evolutionary conserved proteins acting as ligand-activated transcription factors. Functionally, NRs are essential in embryogenesis and organogenesis and in adulthood they are involved in almost every physiological and pathological process. Our knowledge of NRs action has greatly improved in recent years, demonstrating that both their expression and activity are tightly regulated by a network of signaling pathways, miRNA and reciprocal interactions. The Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII, NR2F2) is a NR classified as an orphan due to the lack of a known natural ligand. Although its expression peaks during development, and then decreases considerably, in adult tissues, COUP-TFII is an important regulator of differentiation and it is variably implicated in tissues homeostasis. As such, alterations of its expression or its transcriptional activity have been studied and linked to a spectrum of diseases in organs and tissues of different origins. Indeed, an altered COUP-TFII expression and activity may cause infertility, abnormality in the vascular system and metabolic diseases like diabetes. Moreover, COUP-TFII is actively investigated in cancer research but its role in tumor progression is yet to be fully understood. In this review, we summarize the current understanding of COUP-TFII in healthy and pathological conditions, proposing an updated and critical view of the many functions of this NR.https://www.mdpi.com/2073-4409/9/1/101nr2f2coup-tfiicancermetabolismnf-κbemtangiogenesisdevelopmentmetabolism |
| spellingShingle | Simone Polvani Sara Pepe Stefano Milani Andrea Galli COUP-TFII in Health and Disease Cells nr2f2 coup-tfii cancer metabolism nf-κb emt angiogenesis development metabolism |
| title | COUP-TFII in Health and Disease |
| title_full | COUP-TFII in Health and Disease |
| title_fullStr | COUP-TFII in Health and Disease |
| title_full_unstemmed | COUP-TFII in Health and Disease |
| title_short | COUP-TFII in Health and Disease |
| title_sort | coup tfii in health and disease |
| topic | nr2f2 coup-tfii cancer metabolism nf-κb emt angiogenesis development metabolism |
| url | https://www.mdpi.com/2073-4409/9/1/101 |
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