Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period
<i>Background and objectives:</i> Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been de...
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MDPI AG
2020-01-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1010-660X/56/1/37 |
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| author | Angel Yordanov Martin Karamanliev Latchezar Tantchev Assia Konsoulova Strahil Strashilov Mariela Vasileva-Slaveva |
| author_facet | Angel Yordanov Martin Karamanliev Latchezar Tantchev Assia Konsoulova Strahil Strashilov Mariela Vasileva-Slaveva |
| author_sort | Angel Yordanov |
| collection | DOAJ |
| description | <i>Background and objectives:</i> Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been described as having the appearance of a squamous cell carcinoma without glandular formation and contains intracellular mucin. The postoperative evolution of this tumor and the potentially poorer prognosis may indicate an intensification of the follow-up. The objective of our study was to analyze the frequency of mucoepidermoid carcinoma in hospitalized women with cervical cancer, clinical characteristics and prognosis. <i>Material and Methods:</i> A retrospective study of all cases of mucoepidermoid carcinoma of the cervix at Department of Gynecologic Oncology, University Hospital—Pleven, Pleven Bulgaria between 1 January 2007 and 31 December 2016 was performed. All patients were followed-up till December 2019. We analyzed certain clinical characteristics of the patients; calculated the frequency of mucoepidermoid carcinoma of the cervix from all patients with stage I cervical cancer; and looked at the overall survival rate, correlation between overall survival, lymph node status and the size of the tumor. <i>Results:</i> The frequency of MEC was 1.12% of all patients with stage I cervical cancer in this study. The median age of the patients with MEC was 46.7 years (range 38−62). Four patients (57.1%) were staged as FIGO IB1, and three patients (42.8%) were FIGO IB2. The size of the primary tumor was <2 cm in 2 patients (28.57%), 2−4 cm in 2 patients (28.57%) and >4 cm in 3 patients (42.8%). Metastatic lymph nodes were found in two patients (28.57%), and nonmetastatic lymph nodes were found in five patients (71.43%). There were two (28.57%) disease-related deaths during the study period. The five-year observed survival in the MEC group was 85.7% and in the other subtypes of adenosquamous cancer group was 78.3%. <i>Conclusions:</i> MEC of the uterine cervix is a rare entity diagnosis. As a mucin-producing tumor, it is frequently regarded as a subtype with worse clinical behavior and patients’ outcomes. Nevertheless, our data did not confirm this prognosis. New molecular markers and better stratification are needed for better selection of patients with CC, which may benefit more from additional treatment and new target therapies. |
| first_indexed | 2024-03-12T11:11:29Z |
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| last_indexed | 2024-03-12T11:11:29Z |
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| spelling | doaj.art-4161e41db62c4445967df6a377a05d802023-09-02T02:50:54ZengMDPI AGMedicina1010-660X2020-01-015613710.3390/medicina56010037medicina56010037Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year PeriodAngel Yordanov0Martin Karamanliev1Latchezar Tantchev2Assia Konsoulova3Strahil Strashilov4Mariela Vasileva-Slaveva5Department of Gynecologic Oncology, Medical University Pleven, 5800 Pleven, BulgariaDepartment of Surgical Oncology, Medical University Pleven, 5800 Pleven, BulgariaObstetrics and Gynecology Clinic, Acibadem City Clinic Hospital “Tokuda”, PC 1000 Sofia City, BulgariaDepartment of Medical Oncology, Complex Oncological Center Burgas, 8000 Burgas, BulgariaDepartment of plastic and reconstructive surgery, MU-Pleven, 5800 Pleven, BulgariaEXTRO-Lab, Department of Therapeutic Radiology and Oncology, Medical University of Innsbruck, 6020 Innsbruck, Austria<i>Background and objectives:</i> Adenosquamous cancer of the uterine cervix is a rare type of cervical cancer with both malignant squamous and glandular components. A very rare subtype is mucoepidermoid carcinoma (MEC), which was first described as a salivary gland tumor. It has been described as having the appearance of a squamous cell carcinoma without glandular formation and contains intracellular mucin. The postoperative evolution of this tumor and the potentially poorer prognosis may indicate an intensification of the follow-up. The objective of our study was to analyze the frequency of mucoepidermoid carcinoma in hospitalized women with cervical cancer, clinical characteristics and prognosis. <i>Material and Methods:</i> A retrospective study of all cases of mucoepidermoid carcinoma of the cervix at Department of Gynecologic Oncology, University Hospital—Pleven, Pleven Bulgaria between 1 January 2007 and 31 December 2016 was performed. All patients were followed-up till December 2019. We analyzed certain clinical characteristics of the patients; calculated the frequency of mucoepidermoid carcinoma of the cervix from all patients with stage I cervical cancer; and looked at the overall survival rate, correlation between overall survival, lymph node status and the size of the tumor. <i>Results:</i> The frequency of MEC was 1.12% of all patients with stage I cervical cancer in this study. The median age of the patients with MEC was 46.7 years (range 38−62). Four patients (57.1%) were staged as FIGO IB1, and three patients (42.8%) were FIGO IB2. The size of the primary tumor was <2 cm in 2 patients (28.57%), 2−4 cm in 2 patients (28.57%) and >4 cm in 3 patients (42.8%). Metastatic lymph nodes were found in two patients (28.57%), and nonmetastatic lymph nodes were found in five patients (71.43%). There were two (28.57%) disease-related deaths during the study period. The five-year observed survival in the MEC group was 85.7% and in the other subtypes of adenosquamous cancer group was 78.3%. <i>Conclusions:</i> MEC of the uterine cervix is a rare entity diagnosis. As a mucin-producing tumor, it is frequently regarded as a subtype with worse clinical behavior and patients’ outcomes. Nevertheless, our data did not confirm this prognosis. New molecular markers and better stratification are needed for better selection of patients with CC, which may benefit more from additional treatment and new target therapies.https://www.mdpi.com/1010-660X/56/1/37mucoepidermoid cervical carcinomaadenosquamous carcinomasurvival ratelymph node involvment |
| spellingShingle | Angel Yordanov Martin Karamanliev Latchezar Tantchev Assia Konsoulova Strahil Strashilov Mariela Vasileva-Slaveva Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period Medicina mucoepidermoid cervical carcinoma adenosquamous carcinoma survival rate lymph node involvment |
| title | Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period |
| title_full | Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period |
| title_fullStr | Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period |
| title_full_unstemmed | Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period |
| title_short | Mucoepidermoid Carcinoma of the Uterine Cervix—Single-Center Study Over a 10-Year Period |
| title_sort | mucoepidermoid carcinoma of the uterine cervix single center study over a 10 year period |
| topic | mucoepidermoid cervical carcinoma adenosquamous carcinoma survival rate lymph node involvment |
| url | https://www.mdpi.com/1010-660X/56/1/37 |
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