Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice
ObjectiveThe purpose of this study was to determine the effect of quercetin on the antitumor activity of cisplatin and its side-effects.MethodsEMT6 cells, a mouse breast cancer cell line, were injected subcutaneously in mice to generate a breast tumor-bearing mouse model. Experimental groups were di...
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| Format: | Article |
| Language: | English |
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Korean Society of Obstetrics and Gynecology
2019-07-01
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| Series: | Obstetrics & Gynecology Science |
| Subjects: | |
| Online Access: | http://ogscience.org/upload/pdf/ogs-62-242.pdf |
| _version_ | 1818419443039993856 |
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| author | Hyunju Liu Jung In Lee Tae-Gyu Ahn |
| author_facet | Hyunju Liu Jung In Lee Tae-Gyu Ahn |
| author_sort | Hyunju Liu |
| collection | DOAJ |
| description | ObjectiveThe purpose of this study was to determine the effect of quercetin on the antitumor activity of cisplatin and its side-effects.MethodsEMT6 cells, a mouse breast cancer cell line, were injected subcutaneously in mice to generate a breast tumor-bearing mouse model. Experimental groups were divided into four groups: control (C), quercetin (Q), cisplatin (CP), and cisplatin+quercetin (CP+Q).ResultsThe tumor volume of the CP+Q group was significantly lower than that of the CP group. Serum blood urea nitrogen and creatinine levels in the CP+Q group were lower than those in the CP group. Renal γ-glutamyltranspeptidase and alkaline phosphatase activities were significantly higher in the CP+Q group than in the CP group, and the content of renal thiobarbituric acid reactive substance was significantly lower in the CP+Q group than that in the CP group. These results suggested that quercetin and cisplatin synergistically increased cellular toxicity in breast cancer cells and mediated cancer growth inhibition, thereby enhancing the antitumor effect of cisplatin compared to when only cisplatin was administered. Quercetin also reduced renal toxicity, which arose as a potential a side effect of cisplatin.ConclusionThe enhanced antitumor effect of cisplatin and decreased renal toxicity after quercetin treatment suggested the applicability of quercetin as an adjuvant for chemotherapeutic agents. |
| first_indexed | 2024-12-14T12:38:39Z |
| format | Article |
| id | doaj.art-41637d72552844b3bc34cec8c491d6dc |
| institution | Directory Open Access Journal |
| issn | 2287-8572 2287-8580 |
| language | English |
| last_indexed | 2024-12-14T12:38:39Z |
| publishDate | 2019-07-01 |
| publisher | Korean Society of Obstetrics and Gynecology |
| record_format | Article |
| series | Obstetrics & Gynecology Science |
| spelling | doaj.art-41637d72552844b3bc34cec8c491d6dc2022-12-21T23:00:58ZengKorean Society of Obstetrics and GynecologyObstetrics & Gynecology Science2287-85722287-85802019-07-0162424224810.5468/ogs.2019.62.4.242580Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing miceHyunju Liu0Jung In Lee1Tae-Gyu Ahn2Department of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, .KoreaDepartment of Internal Medicine, College of Medicine, Chosun University, Gwangju, .KoreaDepartment of Obstetrics and Gynecology, College of Medicine, Chosun University, Gwangju, .KoreaObjectiveThe purpose of this study was to determine the effect of quercetin on the antitumor activity of cisplatin and its side-effects.MethodsEMT6 cells, a mouse breast cancer cell line, were injected subcutaneously in mice to generate a breast tumor-bearing mouse model. Experimental groups were divided into four groups: control (C), quercetin (Q), cisplatin (CP), and cisplatin+quercetin (CP+Q).ResultsThe tumor volume of the CP+Q group was significantly lower than that of the CP group. Serum blood urea nitrogen and creatinine levels in the CP+Q group were lower than those in the CP group. Renal γ-glutamyltranspeptidase and alkaline phosphatase activities were significantly higher in the CP+Q group than in the CP group, and the content of renal thiobarbituric acid reactive substance was significantly lower in the CP+Q group than that in the CP group. These results suggested that quercetin and cisplatin synergistically increased cellular toxicity in breast cancer cells and mediated cancer growth inhibition, thereby enhancing the antitumor effect of cisplatin compared to when only cisplatin was administered. Quercetin also reduced renal toxicity, which arose as a potential a side effect of cisplatin.ConclusionThe enhanced antitumor effect of cisplatin and decreased renal toxicity after quercetin treatment suggested the applicability of quercetin as an adjuvant for chemotherapeutic agents.http://ogscience.org/upload/pdf/ogs-62-242.pdfquercetincisplatinbreast cancerrenal injury |
| spellingShingle | Hyunju Liu Jung In Lee Tae-Gyu Ahn Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice Obstetrics & Gynecology Science quercetin cisplatin breast cancer renal injury |
| title | Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice |
| title_full | Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice |
| title_fullStr | Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice |
| title_full_unstemmed | Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice |
| title_short | Effect of quercetin on the anti-tumor activity of cisplatin in EMT6 breast tumor-bearing mice |
| title_sort | effect of quercetin on the anti tumor activity of cisplatin in emt6 breast tumor bearing mice |
| topic | quercetin cisplatin breast cancer renal injury |
| url | http://ogscience.org/upload/pdf/ogs-62-242.pdf |
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