Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age
Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative conse...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-12-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/16/1/63 |
| _version_ | 1797358319823749120 |
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| author | Giuseppe Lisco Olga Eugenia Disoteo Anna De Tullio Vincenzo De Geronimo Vito Angelo Giagulli Fabio Monzani Emilio Jirillo Renato Cozzi Edoardo Guastamacchia Giovanni De Pergola Vincenzo Triggiani |
| author_facet | Giuseppe Lisco Olga Eugenia Disoteo Anna De Tullio Vincenzo De Geronimo Vito Angelo Giagulli Fabio Monzani Emilio Jirillo Renato Cozzi Edoardo Guastamacchia Giovanni De Pergola Vincenzo Triggiani |
| author_sort | Giuseppe Lisco |
| collection | DOAJ |
| description | Sarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk of falls, frailty, overall quality of life, and mortality. PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched for research articles, scientific reports, observational studies, clinical trials, narrative and systematic reviews, and meta-analyses to review the evidence on the pathophysiology of di-abetes-induced sarcopenia, its relevance in terms of glucose control and diabetes-related outcomes, and diagnostic and therapeutic challenges. The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D. |
| first_indexed | 2024-03-08T15:00:13Z |
| format | Article |
| id | doaj.art-4164568dbdfa4d1b90a2cf0cb11b0cbb |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-08T15:00:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-4164568dbdfa4d1b90a2cf0cb11b0cbb2024-01-10T15:05:24ZengMDPI AGNutrients2072-66432023-12-011616310.3390/nu16010063Sarcopenia and Diabetes: A Detrimental Liaison of Advancing AgeGiuseppe Lisco0Olga Eugenia Disoteo1Anna De Tullio2Vincenzo De Geronimo3Vito Angelo Giagulli4Fabio Monzani5Emilio Jirillo6Renato Cozzi7Edoardo Guastamacchia8Giovanni De Pergola9Vincenzo Triggiani10Section of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyUnit of Endocrinology, Diabetology, Dietetics and Clinical Nutrition, Sant Anna Hospital, 22020 San Fermo della Battaglia, ItalySection of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyUnit of Endocrinology, Clinical Diagnostic Center Morgagni, 95100 Catania, ItalySection of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyGeriatrics Unit, Department of Clinical & Experimental Medicine, University of Pisa, 56126 Pisa, ItalySection of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyDivision of Endocrinology, Niguarda Hospital, 20162 Milan, ItalySection of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalyCenter of Nutrition for the Research and the Care of Obesity and Metabolic Diseases, National Institute of Gastroenterology IRCCS “Saverio de Bellis”, 70013 Castellana Grotte, ItalySection of Internal Medicine, Geriatrics, Endocrinology and Rare Diseases, Interdisciplinary Department of Medicine, University of Bari “Aldo Moro”, 70124 Bari, ItalySarcopenia is an age-related clinical complaint characterized by the progressive deterioration of skeletal muscle mass and strength over time. Type 2 diabetes (T2D) is associated with faster and more relevant skeletal muscle impairment. Both conditions influence each other, leading to negative consequences on glycemic control, cardiovascular risk, general health status, risk of falls, frailty, overall quality of life, and mortality. PubMed/Medline, Scopus, Web of Science, and Google Scholar were searched for research articles, scientific reports, observational studies, clinical trials, narrative and systematic reviews, and meta-analyses to review the evidence on the pathophysiology of di-abetes-induced sarcopenia, its relevance in terms of glucose control and diabetes-related outcomes, and diagnostic and therapeutic challenges. The review comprehensively addresses key elements for the clinical definition and diagnostic criteria of sarcopenia, the pathophysiological correlation be-tween T2D, sarcopenia, and related outcomes, a critical review of the role of antihyperglycemic treatment on skeletal muscle health, and perspectives on the role of specific treatment targeting myokine signaling pathways involved in glucose control and the regulation of skeletal muscle metabolism and trophism. Prompt diagnosis and adequate management, including lifestyle inter-vention, health diet programs, micronutrient supplementation, physical exercise, and pharmaco-logical treatment, are needed to prevent or delay skeletal muscle deterioration in T2D.https://www.mdpi.com/2072-6643/16/1/63sarcopeniadiabetes mellitusobesityagingphysical exerciseprotein supplementation |
| spellingShingle | Giuseppe Lisco Olga Eugenia Disoteo Anna De Tullio Vincenzo De Geronimo Vito Angelo Giagulli Fabio Monzani Emilio Jirillo Renato Cozzi Edoardo Guastamacchia Giovanni De Pergola Vincenzo Triggiani Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age Nutrients sarcopenia diabetes mellitus obesity aging physical exercise protein supplementation |
| title | Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age |
| title_full | Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age |
| title_fullStr | Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age |
| title_full_unstemmed | Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age |
| title_short | Sarcopenia and Diabetes: A Detrimental Liaison of Advancing Age |
| title_sort | sarcopenia and diabetes a detrimental liaison of advancing age |
| topic | sarcopenia diabetes mellitus obesity aging physical exercise protein supplementation |
| url | https://www.mdpi.com/2072-6643/16/1/63 |
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