Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report
Abstract Background Previous studied revealed that psoriasis and Inflammatory bowel disease (IBD) have highly overlapping epidemiological characteristics, genetic susceptibility loci, disease risk factors, immune mechanisms, and comorbidities. More and more biologics have been used to treat psoriasi...
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| Format: | Article |
| Language: | English |
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BMC
2020-10-01
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| Series: | BMC Gastroenterology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12876-020-01474-x |
| _version_ | 1818212117981954048 |
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| author | Jingyi Ju Yuanyuan Dai Jiaolan Yang Changqin Liu Li Fan Lijin Feng Binghui Zhao Meiying Zeng Zhanju Liu Xiaomin Sun |
| author_facet | Jingyi Ju Yuanyuan Dai Jiaolan Yang Changqin Liu Li Fan Lijin Feng Binghui Zhao Meiying Zeng Zhanju Liu Xiaomin Sun |
| author_sort | Jingyi Ju |
| collection | DOAJ |
| description | Abstract Background Previous studied revealed that psoriasis and Inflammatory bowel disease (IBD) have highly overlapping epidemiological characteristics, genetic susceptibility loci, disease risk factors, immune mechanisms, and comorbidities. More and more biologics have been used to treat psoriasis and IBD. Interleukin (IL)-17 inhibitors played an important role in the treatment of psoriasis, but induced and aggravated inflammatory bowel disease in some patients. IL-23 inhibitors have shown to be effective to both psoriasis and CD. Case presentation Forty-one year old Chinese male patient who came to the hospital for psoriasis, developed severe gastrointestinal symptoms after using an IL-17 inhibitor, and was diagnosed with Crohn’s disease (CD). The patient eventually used an IL-23 inhibitor to relieve both psoriasis and CD. Conclusion IBD patients and psoriasis patients have increased probability of suffering from the other disease. The case that patients had suffered from psoriasis and CD before the use of IL-17 inhibitor is quite rare. This case suggests that physicians need to be careful when treating patients with psoriasis and CD with biologics, and it is necessary to evaluate the gastrointestinal tract. |
| first_indexed | 2024-12-12T05:43:18Z |
| format | Article |
| id | doaj.art-41649208203445158def7244bdb8c78b |
| institution | Directory Open Access Journal |
| issn | 1471-230X |
| language | English |
| last_indexed | 2024-12-12T05:43:18Z |
| publishDate | 2020-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Gastroenterology |
| spelling | doaj.art-41649208203445158def7244bdb8c78b2022-12-22T00:35:51ZengBMCBMC Gastroenterology1471-230X2020-10-012011710.1186/s12876-020-01474-xCrohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case reportJingyi Ju0Yuanyuan Dai1Jiaolan Yang2Changqin Liu3Li Fan4Lijin Feng5Binghui Zhao6Meiying Zeng7Zhanju Liu8Xiaomin Sun9Department of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Pathology, Shanghai Tenth People’s Hospital, Tongji UniversityDepartment of Radiology, Shanghai Tenth People’s Hospital, Tongji UniversityDepartment of Radiology, Shanghai Tenth People’s Hospital, Tongji UniversityDepartment of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji UniversityDepartment of Gastroenterology, Shanghai Tenth People’s Hospital of Tongji UniversityAbstract Background Previous studied revealed that psoriasis and Inflammatory bowel disease (IBD) have highly overlapping epidemiological characteristics, genetic susceptibility loci, disease risk factors, immune mechanisms, and comorbidities. More and more biologics have been used to treat psoriasis and IBD. Interleukin (IL)-17 inhibitors played an important role in the treatment of psoriasis, but induced and aggravated inflammatory bowel disease in some patients. IL-23 inhibitors have shown to be effective to both psoriasis and CD. Case presentation Forty-one year old Chinese male patient who came to the hospital for psoriasis, developed severe gastrointestinal symptoms after using an IL-17 inhibitor, and was diagnosed with Crohn’s disease (CD). The patient eventually used an IL-23 inhibitor to relieve both psoriasis and CD. Conclusion IBD patients and psoriasis patients have increased probability of suffering from the other disease. The case that patients had suffered from psoriasis and CD before the use of IL-17 inhibitor is quite rare. This case suggests that physicians need to be careful when treating patients with psoriasis and CD with biologics, and it is necessary to evaluate the gastrointestinal tract.http://link.springer.com/article/10.1186/s12876-020-01474-xPsoriasisInflammatory bowel diseaseCrohn’s diseaseIL-17 inhibitorIL-23 inhibitor |
| spellingShingle | Jingyi Ju Yuanyuan Dai Jiaolan Yang Changqin Liu Li Fan Lijin Feng Binghui Zhao Meiying Zeng Zhanju Liu Xiaomin Sun Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report BMC Gastroenterology Psoriasis Inflammatory bowel disease Crohn’s disease IL-17 inhibitor IL-23 inhibitor |
| title | Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report |
| title_full | Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report |
| title_fullStr | Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report |
| title_full_unstemmed | Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report |
| title_short | Crohn’s disease exacerbated by IL-17 inhibitors in patients with psoriasis: a case report |
| title_sort | crohn s disease exacerbated by il 17 inhibitors in patients with psoriasis a case report |
| topic | Psoriasis Inflammatory bowel disease Crohn’s disease IL-17 inhibitor IL-23 inhibitor |
| url | http://link.springer.com/article/10.1186/s12876-020-01474-x |
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