Activation, function and content of platelets in burn patients
Burn injury has severe impact on the physiologic homeostasis. Platelet counts show a distinct course post-burn injury, with a nadir at day 3 followed by a thrombocytotic period with at peak at day 15, with a gradual return to normal. So far, it is unknown how the functionality and activational statu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-04-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2018.1448379 |
| _version_ | 1797684258449391616 |
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| author | Roos E. Marck Ivo van der Bijl Herbert Korsten Jos Lorinser Dirk de Korte Esther Middelkoop |
| author_facet | Roos E. Marck Ivo van der Bijl Herbert Korsten Jos Lorinser Dirk de Korte Esther Middelkoop |
| author_sort | Roos E. Marck |
| collection | DOAJ |
| description | Burn injury has severe impact on the physiologic homeostasis. Platelet counts show a distinct course post-burn injury, with a nadir at day 3 followed by a thrombocytotic period with at peak at day 15, with a gradual return to normal. So far, it is unknown how the functionality and activational status of platelets develop post burn. In this study, we investigated if the function, activation and growth factor content of platelets of burn patients are affected and how this evolves in time. Six burn patients with over 15% total burned surface area were followed during 1 month. Standard hematological and coagulation analyses, thromboelastography (TEG), platelet-function analyzer-100 (PFA), several platelet activation parameters (CD62P-CD63, AnnexinV) and growth factors (TGFb1, VEGF, PDGF-AB/BB, EGF, TGFb2, FGF-2, PDGF-AA) analyses were performed. TEG analyses showed procoagulant changes. PFA-100 analyses were nearly all within normal range. CD62P and CD63 and Annexin-V indicated no clear activation of platelets. Growth factor content followed the same course as the platelet count, reflecting a constant growth factor per platelet ratio. Concluding, platelets post burn-injury appears to be functional and not overly activated. However, burn patients seem to remain in a procoagulant state for an extensive period, which may impact their pathology. |
| first_indexed | 2024-03-12T00:26:58Z |
| format | Article |
| id | doaj.art-416671926f5f454481d1398ae6aa71ee |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:26:58Z |
| publishDate | 2019-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-416671926f5f454481d1398ae6aa71ee2023-09-15T10:31:59ZengTaylor & Francis GroupPlatelets0953-71041369-16352019-04-0130339640210.1080/09537104.2018.14483791448379Activation, function and content of platelets in burn patientsRoos E. Marck0Ivo van der Bijl1Herbert Korsten2Jos Lorinser3Dirk de Korte4Esther Middelkoop5Academical Medical CenterAcademic Medical Center, University of AmsterdamSanquin Blood BankSanquin Blood BankAcademic Medical Center, University of AmsterdamRed Cross HospitalBurn injury has severe impact on the physiologic homeostasis. Platelet counts show a distinct course post-burn injury, with a nadir at day 3 followed by a thrombocytotic period with at peak at day 15, with a gradual return to normal. So far, it is unknown how the functionality and activational status of platelets develop post burn. In this study, we investigated if the function, activation and growth factor content of platelets of burn patients are affected and how this evolves in time. Six burn patients with over 15% total burned surface area were followed during 1 month. Standard hematological and coagulation analyses, thromboelastography (TEG), platelet-function analyzer-100 (PFA), several platelet activation parameters (CD62P-CD63, AnnexinV) and growth factors (TGFb1, VEGF, PDGF-AB/BB, EGF, TGFb2, FGF-2, PDGF-AA) analyses were performed. TEG analyses showed procoagulant changes. PFA-100 analyses were nearly all within normal range. CD62P and CD63 and Annexin-V indicated no clear activation of platelets. Growth factor content followed the same course as the platelet count, reflecting a constant growth factor per platelet ratio. Concluding, platelets post burn-injury appears to be functional and not overly activated. However, burn patients seem to remain in a procoagulant state for an extensive period, which may impact their pathology.http://dx.doi.org/10.1080/09537104.2018.1448379burngrowth factorplateletplatelet functionplatelet rich plasma |
| spellingShingle | Roos E. Marck Ivo van der Bijl Herbert Korsten Jos Lorinser Dirk de Korte Esther Middelkoop Activation, function and content of platelets in burn patients Platelets burn growth factor platelet platelet function platelet rich plasma |
| title | Activation, function and content of platelets in burn patients |
| title_full | Activation, function and content of platelets in burn patients |
| title_fullStr | Activation, function and content of platelets in burn patients |
| title_full_unstemmed | Activation, function and content of platelets in burn patients |
| title_short | Activation, function and content of platelets in burn patients |
| title_sort | activation function and content of platelets in burn patients |
| topic | burn growth factor platelet platelet function platelet rich plasma |
| url | http://dx.doi.org/10.1080/09537104.2018.1448379 |
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