HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients
Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients show lower humoral vaccine responsiveness than immunocompetent individuals. HLA diversity, measured by the HLA evolutionary divergence (HED) metrics, reflects the diversity of the antigenic repertoire presented to T c...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-05-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223008404 |
| _version_ | 1797829475832954880 |
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| author | Juliette Villemonteix Vincent Allain Emma Verstraete Debora Jorge-Cordeiro Gérard Socié Alienor Xhaard Cyrille Feray Sophie Caillat-Zucman |
| author_facet | Juliette Villemonteix Vincent Allain Emma Verstraete Debora Jorge-Cordeiro Gérard Socié Alienor Xhaard Cyrille Feray Sophie Caillat-Zucman |
| author_sort | Juliette Villemonteix |
| collection | DOAJ |
| description | Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients show lower humoral vaccine responsiveness than immunocompetent individuals. HLA diversity, measured by the HLA evolutionary divergence (HED) metrics, reflects the diversity of the antigenic repertoire presented to T cells, and has been shown to predict response to cancer immunotherapy. We retrospectively investigated the association of HED with humoral response to SARS-CoV-2 vaccine in allo-HSCT recipients. HED was calculated as pairwise genetic distance between alleles at HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 loci in recipients and their donors. Low anti-spike IgG levels (<30 BAU/mL) were associated with short time from allo-SCT and low donor DPB1-HED, mostly related to donor DPB1 homozygosity. The diversity of donor HLA-DP molecules, assessed by heterozygosity or sequence divergence, may thus impact the efficacy of donor-derived CD4 T cells to sustain vaccine-mediated antibody response in allo-HSCT recipients. |
| first_indexed | 2024-04-09T13:21:52Z |
| format | Article |
| id | doaj.art-4166ce01ee8a4950a9a8f00deb869a9b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-04-09T13:21:52Z |
| publishDate | 2023-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-4166ce01ee8a4950a9a8f00deb869a9b2023-05-11T04:24:36ZengElsevieriScience2589-00422023-05-01265106763HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipientsJuliette Villemonteix0Vincent Allain1Emma Verstraete2Debora Jorge-Cordeiro3Gérard Socié4Alienor Xhaard5Cyrille Feray6Sophie Caillat-Zucman7Laboratoire d’Immunologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, 75010 Paris, FranceLaboratoire d’Immunologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, 75010 Paris, France; INSERM UMR 976, Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), 75010 Paris, FranceService d’hématologie-greffe, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 75010 Paris, FranceLaboratoire d’Immunologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, 75010 Paris, FranceINSERM UMR 976, Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), 75010 Paris, France; Service d’hématologie-greffe, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 75010 Paris, FranceService d’hématologie-greffe, Hôpital Saint-Louis, AP-HP, Université Paris Cité, 75010 Paris, FranceCentre Hépato-Biliaire, Hôpital Paul-Brousse, AP-HP, Université Paris-Saclay, FHU Hepatinov, 94800 Villejuif, France; Institut National de la santé et de la recherche médicale (INSERM) UMR-S 1193, 94800 Villejuif, FranceLaboratoire d’Immunologie, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris (AP-HP), Université Paris Cité, 75010 Paris, France; INSERM UMR 976, Université Paris Cité, Institut de Recherche Saint-Louis (IRSL), 75010 Paris, France; Corresponding authorSummary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients show lower humoral vaccine responsiveness than immunocompetent individuals. HLA diversity, measured by the HLA evolutionary divergence (HED) metrics, reflects the diversity of the antigenic repertoire presented to T cells, and has been shown to predict response to cancer immunotherapy. We retrospectively investigated the association of HED with humoral response to SARS-CoV-2 vaccine in allo-HSCT recipients. HED was calculated as pairwise genetic distance between alleles at HLA-A, -B, -C, -DRB1, -DQB1, and -DPB1 loci in recipients and their donors. Low anti-spike IgG levels (<30 BAU/mL) were associated with short time from allo-SCT and low donor DPB1-HED, mostly related to donor DPB1 homozygosity. The diversity of donor HLA-DP molecules, assessed by heterozygosity or sequence divergence, may thus impact the efficacy of donor-derived CD4 T cells to sustain vaccine-mediated antibody response in allo-HSCT recipients.http://www.sciencedirect.com/science/article/pii/S2589004223008404ImmunologyVirology |
| spellingShingle | Juliette Villemonteix Vincent Allain Emma Verstraete Debora Jorge-Cordeiro Gérard Socié Alienor Xhaard Cyrille Feray Sophie Caillat-Zucman HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients iScience Immunology Virology |
| title | HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients |
| title_full | HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients |
| title_fullStr | HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients |
| title_full_unstemmed | HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients |
| title_short | HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients |
| title_sort | hla dp diversity is associated with improved response to sars cov 2 vaccine in hematopoietic stem cell transplant recipients |
| topic | Immunology Virology |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223008404 |
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