HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients

HLA-DP diversity is associated with improved response to SARS-Cov-2 vaccine in hematopoietic stem cell transplant recipients

Summary: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) recipients show lower humoral vaccine responsiveness than immunocompetent individuals. HLA diversity, measured by the HLA evolutionary divergence (HED) metrics, reflects the diversity of the antigenic repertoire presented to T c...

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Bibliographic Details
Main Authors: Juliette Villemonteix, Vincent Allain, Emma Verstraete, Debora Jorge-Cordeiro, Gérard Socié, Alienor Xhaard, Cyrille Feray, Sophie Caillat-Zucman
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:iScience
Subjects:
Immunology
Virology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223008404

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