Acute HIV infection with rapid progression to AIDS
Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
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| Series: | Brazilian Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016&lng=en&tlng=en |
| _version_ | 1830491835874672640 |
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| author | Marcio de Oliveira Silva Milena Bastos Eduardo Martins Netto Nancy Alves de Lima Gouvea Alex Jose Leite Torres Esper Kallas David I Watkins Marcus Altfeld Carlos Brites |
| author_facet | Marcio de Oliveira Silva Milena Bastos Eduardo Martins Netto Nancy Alves de Lima Gouvea Alex Jose Leite Torres Esper Kallas David I Watkins Marcus Altfeld Carlos Brites |
| author_sort | Marcio de Oliveira Silva |
| collection | DOAJ |
| description | Acute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable. |
| first_indexed | 2024-12-21T20:18:21Z |
| format | Article |
| id | doaj.art-4168c9fae27e44f1be5c7288937c176a |
| institution | Directory Open Access Journal |
| issn | 1678-4391 |
| language | English |
| last_indexed | 2024-12-21T20:18:21Z |
| publisher | Elsevier |
| record_format | Article |
| series | Brazilian Journal of Infectious Diseases |
| spelling | doaj.art-4168c9fae27e44f1be5c7288937c176a2022-12-21T18:51:32ZengElsevierBrazilian Journal of Infectious Diseases1678-439114329129310.1590/S1413-86702010000300016S1413-86702010000300016Acute HIV infection with rapid progression to AIDSMarcio de Oliveira Silva0Milena Bastos1Eduardo Martins Netto2Nancy Alves de Lima Gouvea3Alex Jose Leite Torres4Esper Kallas5David I Watkins6Marcus Altfeld7Carlos Brites8Universidade Federal da BahiaUniversidade Federal da BahiaUniversidade Federal da BahiaUniversidade de São PauloUniversidade Federal da BahiaUniversidade de São PauloWisconsin National Primate ResearchMassachusetts General HospitalUniversidade Federal da BahiaAcute HIV infection is rarely recognized as the signs and symptoms are normally unspecific and can persist for days or weeks. The normal HIV course is characterized by a progressive loss of CD4+ cells, which normally leads to severe immunodeficiency after a variable time interval. The mean time from initial infection to development of clinical AIDS is approximately 8-10 years, but it is variable among individuals and depends on a complex interaction between virus and host. Here we describe an extraordinary case of a man who developed Pneumocisits jiroveci pneumonia within one month after sexual exposure to HIV-1, and then presented with 3 consecutive CD4 counts bellow 200 cells/mm³ within 3 months, with no other opportunistic disease. Although antiretroviral therapy (AZT+3TC+ATZ/r) was started, with full adherence of the patient, and genotyping indicating no primary antiretroviral resistance mutations, he required more than six months to have a CD4 restoration to levels above 200 cells/mm³ and 10 months to HIV-RNA to become undetectable.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016&lng=en&tlng=enHIVacute infectionprogressionAIDS |
| spellingShingle | Marcio de Oliveira Silva Milena Bastos Eduardo Martins Netto Nancy Alves de Lima Gouvea Alex Jose Leite Torres Esper Kallas David I Watkins Marcus Altfeld Carlos Brites Acute HIV infection with rapid progression to AIDS Brazilian Journal of Infectious Diseases HIV acute infection progression AIDS |
| title | Acute HIV infection with rapid progression to AIDS |
| title_full | Acute HIV infection with rapid progression to AIDS |
| title_fullStr | Acute HIV infection with rapid progression to AIDS |
| title_full_unstemmed | Acute HIV infection with rapid progression to AIDS |
| title_short | Acute HIV infection with rapid progression to AIDS |
| title_sort | acute hiv infection with rapid progression to aids |
| topic | HIV acute infection progression AIDS |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702010000300016&lng=en&tlng=en |
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