Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density
Abstract Background Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under conditions of hyperchloraemia or hyperchloraemic acidosis. To examine...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2021-01-01
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| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-021-03954-x |
| _version_ | 1811270793779216384 |
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| author | Wangna Tang Hongwei Jia Baoping Wang Yun Chai Tong Liu Hao Wang Chenlin Dai |
| author_facet | Wangna Tang Hongwei Jia Baoping Wang Yun Chai Tong Liu Hao Wang Chenlin Dai |
| author_sort | Wangna Tang |
| collection | DOAJ |
| description | Abstract Background Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under conditions of hyperchloraemia or hyperchloraemic acidosis. To examine whether this dysfunction influences the clinical outcome, we explored the distal renal tubular acidification function in patients with PHPT and its effects on the clinical manifestations of the disease. Methods We retrospectively analysed 75 PHPT patients with regard to renal tubular acidification and blood gas analysis. The patients were divided into two groups, the renal tubular acidification dysfunction group and normal function group. Results Serum phosphate level and total hip bone density were significantly decreased and 25OHD level was significantly increased in the renal tubular acidification dysfunction group in comparison to the normal function group. Female patients in the renal tubular acidification dysfunction group showed significantly decreased femoral neck and total hip BMD and increased susceptibility to fracture. However, there were no such differences in male patients between the two groups. Conclusions About 54.6 % of PHPT patients in our study population had abnormal distal renal tubular acidification. PHPT patients with abnormal distal renal tubular acidification may have lower hip bone density. Female PHPT patients with abnormal distal renal tubular acidification showed increased susceptibility to fractures and the development of osteoporosis. |
| first_indexed | 2024-04-12T22:08:27Z |
| format | Article |
| id | doaj.art-4168cbdeaced43cc8fab6e1b9a997224 |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-04-12T22:08:27Z |
| publishDate | 2021-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-4168cbdeaced43cc8fab6e1b9a9972242022-12-22T03:14:50ZengBMCBMC Musculoskeletal Disorders1471-24742021-01-012211610.1186/s12891-021-03954-xEvaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral densityWangna Tang0Hongwei Jia1Baoping Wang2Yun Chai3Tong Liu4Hao Wang5Chenlin Dai6Endocrinology and Metabolism Disease Department, Tianjin Medical University General HospitalEndocrinology and Metabolism Disease Department, Tianjin Medical University General HospitalEndocrinology and Metabolism Disease Department, Tianjin Medical University General HospitalEndocrinology and Metabolism Disease Department, Tianjin Medical University General HospitalEndocrinology and Metabolism Disease Department, Tianjin Medical University General HospitalEndocrinology and Metabolism Disease Department, Tianjin Medical University General HospitalEndocrinology and Metabolism Disease Department, Tianjin Medical University General HospitalAbstract Background Primary hyperparathyroidism (PHPT) is a common endocrinopathy that may increase fracture risk and decrease bone mineral density (BMD). Some patients develop distal renal tubular acidification dysfunction under conditions of hyperchloraemia or hyperchloraemic acidosis. To examine whether this dysfunction influences the clinical outcome, we explored the distal renal tubular acidification function in patients with PHPT and its effects on the clinical manifestations of the disease. Methods We retrospectively analysed 75 PHPT patients with regard to renal tubular acidification and blood gas analysis. The patients were divided into two groups, the renal tubular acidification dysfunction group and normal function group. Results Serum phosphate level and total hip bone density were significantly decreased and 25OHD level was significantly increased in the renal tubular acidification dysfunction group in comparison to the normal function group. Female patients in the renal tubular acidification dysfunction group showed significantly decreased femoral neck and total hip BMD and increased susceptibility to fracture. However, there were no such differences in male patients between the two groups. Conclusions About 54.6 % of PHPT patients in our study population had abnormal distal renal tubular acidification. PHPT patients with abnormal distal renal tubular acidification may have lower hip bone density. Female PHPT patients with abnormal distal renal tubular acidification showed increased susceptibility to fractures and the development of osteoporosis.https://doi.org/10.1186/s12891-021-03954-xPrimary hyperparathyroidismDistal renal tubuleAcidification functionBone mineral density |
| spellingShingle | Wangna Tang Hongwei Jia Baoping Wang Yun Chai Tong Liu Hao Wang Chenlin Dai Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density BMC Musculoskeletal Disorders Primary hyperparathyroidism Distal renal tubule Acidification function Bone mineral density |
| title | Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density |
| title_full | Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density |
| title_fullStr | Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density |
| title_full_unstemmed | Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density |
| title_short | Evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density |
| title_sort | evaluating distal renal tubular acidification function in primary hyperparathyroidism and its effects on bone mineral density |
| topic | Primary hyperparathyroidism Distal renal tubule Acidification function Bone mineral density |
| url | https://doi.org/10.1186/s12891-021-03954-x |
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