A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors
Maladaptive plastic changes in the brain are critical for pain maintenance. The authors identify a nigro–subthalamo–parabrachial pathway and reveal that reversing a series of neuronal and synaptic malfunctions in this pathway in acute and chronic pain mitigates hyperalgesia, providing potential ther...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35474-0 |
| _version_ | 1797980493433536512 |
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| author | Tao Jia Ying-Di Wang Jing Chen Xue Zhang Jun-Li Cao Cheng Xiao Chunyi Zhou |
| author_facet | Tao Jia Ying-Di Wang Jing Chen Xue Zhang Jun-Li Cao Cheng Xiao Chunyi Zhou |
| author_sort | Tao Jia |
| collection | DOAJ |
| description | Maladaptive plastic changes in the brain are critical for pain maintenance. The authors identify a nigro–subthalamo–parabrachial pathway and reveal that reversing a series of neuronal and synaptic malfunctions in this pathway in acute and chronic pain mitigates hyperalgesia, providing potential therapeutic targets for pain modulation. |
| first_indexed | 2024-04-11T05:55:14Z |
| format | Article |
| id | doaj.art-4169aa2620764b608c94c76f24163070 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T05:55:14Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4169aa2620764b608c94c76f241630702022-12-22T04:41:55ZengNature PortfolioNature Communications2041-17232022-12-0113111910.1038/s41467-022-35474-0A nigro–subthalamo–parabrachial pathway modulates pain-like behaviorsTao Jia0Ying-Di Wang1Jing Chen2Xue Zhang3Jun-Li Cao4Cheng Xiao5Chunyi Zhou6Jiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical UniversityJiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical UniversityJiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical UniversityJiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical UniversityJiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical UniversityJiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical UniversityJiangsu Province Key Laboratory in Anesthesiology, School of Anesthesiology, Xuzhou Medical UniversityMaladaptive plastic changes in the brain are critical for pain maintenance. The authors identify a nigro–subthalamo–parabrachial pathway and reveal that reversing a series of neuronal and synaptic malfunctions in this pathway in acute and chronic pain mitigates hyperalgesia, providing potential therapeutic targets for pain modulation.https://doi.org/10.1038/s41467-022-35474-0 |
| spellingShingle | Tao Jia Ying-Di Wang Jing Chen Xue Zhang Jun-Li Cao Cheng Xiao Chunyi Zhou A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors Nature Communications |
| title | A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors |
| title_full | A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors |
| title_fullStr | A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors |
| title_full_unstemmed | A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors |
| title_short | A nigro–subthalamo–parabrachial pathway modulates pain-like behaviors |
| title_sort | nigro subthalamo parabrachial pathway modulates pain like behaviors |
| url | https://doi.org/10.1038/s41467-022-35474-0 |
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