Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the Literature
Xi-Hao Ni,1 Ran An,1 Qian-Wen Shi,2 Chang-Liang Wang3 1School of Clinical Medicine, Weifang Medical University, Weifang, Shandong Province, 261041, People’s Republic of China; 2Newborn Department, Weifang People’s Hospital, Weifang, Shandong Province, 261041, People’s Republic of China; 3Department...
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| Language: | English |
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Dove Medical Press
2023-06-01
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| Series: | OncoTargets and Therapy |
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| Online Access: | https://www.dovepress.com/low-grade-ductal-carcinoma-in-situ-within-a-fibroadenoma-of-the-breast-peer-reviewed-fulltext-article-OTT |
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| author | Ni XH An R Shi QW Wang CL |
| author_facet | Ni XH An R Shi QW Wang CL |
| author_sort | Ni XH |
| collection | DOAJ |
| description | Xi-Hao Ni,1 Ran An,1 Qian-Wen Shi,2 Chang-Liang Wang3 1School of Clinical Medicine, Weifang Medical University, Weifang, Shandong Province, 261041, People’s Republic of China; 2Newborn Department, Weifang People’s Hospital, Weifang, Shandong Province, 261041, People’s Republic of China; 3Department of Breast Surgery, Weifang People’s Hospital, Weifang, Shandong Province, 261041, People’s Republic of ChinaCorrespondence: Chang-Liang Wang, Department of Breast Surgery, Weifang People’s Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang, Shandong Province, 261041, People’s Republic of China, Email wfwangchangl@sina.comBackground: Ductal carcinoma in situ within a breast fibroadenoma is a rare malignancy with an incidence of only 0.02– 0.125%. Imaging of low-grade ductal carcinoma in situ within a breast fibroadenoma shows no specific presentation. Therefore, pathology and immunohistochemistry are required for definitive diagnosis. Surgery is currently considered to be an effective treatment. There is no uniform clinical standard for postoperative adjuvant radiotherapy.Case Summary: A 60-year-old female patient underwent excisional biopsy on October 19, 2022. Pathology and immunohistochemistry confirmed the diagnosis of low-grade ductal carcinoma in situ within the fibroadenoma. Subsequently, breast-conserving surgery and sentinel lymph node biopsy were performed under general anesthesia with tracheal intubation, and no cancer metastasis was observed in the sentinel lymph nodes or incisional margins.Conclusion: Low-grade ductal carcinoma in situ within a breast fibroadenoma is an extremely rare malignancy, and clinicians should be familiar with its clinicopathological features and treatment methods. Multidisciplinary joint treatment is recommended to maximize the benefits to patients.Keywords: breast, fibroadenoma, ductal carcinoma in situ, case report, review of the literature |
| first_indexed | 2024-03-13T01:50:23Z |
| format | Article |
| id | doaj.art-416b4397b55e42aba14cb2842b9b2f86 |
| institution | Directory Open Access Journal |
| issn | 1178-6930 |
| language | English |
| last_indexed | 2024-03-13T01:50:23Z |
| publishDate | 2023-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | OncoTargets and Therapy |
| spelling | doaj.art-416b4397b55e42aba14cb2842b9b2f862023-07-02T19:49:16ZengDove Medical PressOncoTargets and Therapy1178-69302023-06-01Volume 1639940684348Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the LiteratureNi XHAn RShi QWWang CLXi-Hao Ni,1 Ran An,1 Qian-Wen Shi,2 Chang-Liang Wang3 1School of Clinical Medicine, Weifang Medical University, Weifang, Shandong Province, 261041, People’s Republic of China; 2Newborn Department, Weifang People’s Hospital, Weifang, Shandong Province, 261041, People’s Republic of China; 3Department of Breast Surgery, Weifang People’s Hospital, Weifang, Shandong Province, 261041, People’s Republic of ChinaCorrespondence: Chang-Liang Wang, Department of Breast Surgery, Weifang People’s Hospital, No. 151 Guangwen Street, Kuiwen District, Weifang, Shandong Province, 261041, People’s Republic of China, Email wfwangchangl@sina.comBackground: Ductal carcinoma in situ within a breast fibroadenoma is a rare malignancy with an incidence of only 0.02– 0.125%. Imaging of low-grade ductal carcinoma in situ within a breast fibroadenoma shows no specific presentation. Therefore, pathology and immunohistochemistry are required for definitive diagnosis. Surgery is currently considered to be an effective treatment. There is no uniform clinical standard for postoperative adjuvant radiotherapy.Case Summary: A 60-year-old female patient underwent excisional biopsy on October 19, 2022. Pathology and immunohistochemistry confirmed the diagnosis of low-grade ductal carcinoma in situ within the fibroadenoma. Subsequently, breast-conserving surgery and sentinel lymph node biopsy were performed under general anesthesia with tracheal intubation, and no cancer metastasis was observed in the sentinel lymph nodes or incisional margins.Conclusion: Low-grade ductal carcinoma in situ within a breast fibroadenoma is an extremely rare malignancy, and clinicians should be familiar with its clinicopathological features and treatment methods. Multidisciplinary joint treatment is recommended to maximize the benefits to patients.Keywords: breast, fibroadenoma, ductal carcinoma in situ, case report, review of the literaturehttps://www.dovepress.com/low-grade-ductal-carcinoma-in-situ-within-a-fibroadenoma-of-the-breast-peer-reviewed-fulltext-article-OTTbreastfibroadenomaductal carcinoma in situcase reportreview of the literature. |
| spellingShingle | Ni XH An R Shi QW Wang CL Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the Literature OncoTargets and Therapy breast fibroadenoma ductal carcinoma in situ case report review of the literature. |
| title | Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the Literature |
| title_full | Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the Literature |
| title_fullStr | Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the Literature |
| title_full_unstemmed | Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the Literature |
| title_short | Low-Grade Ductal Carcinoma in situ Within a Fibroadenoma of the Breast: A Rare Case Report and Review of the Literature |
| title_sort | low grade ductal carcinoma in situ within a fibroadenoma of the breast a rare case report and review of the literature |
| topic | breast fibroadenoma ductal carcinoma in situ case report review of the literature. |
| url | https://www.dovepress.com/low-grade-ductal-carcinoma-in-situ-within-a-fibroadenoma-of-the-breast-peer-reviewed-fulltext-article-OTT |
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