Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity

Multiplex epigenome editing of ion channel expression in nociceptive neurons abolished degenerative IVD‐conditioned media‐induced mechanical sensitivity

Abstract Background Low back pain is a major contributor to disability worldwide and generates a tremendous socioeconomic impact. The degenerative intervertebral disc (IVD) has been hypothesized to contribute to discogenic pain by sensitizing nociceptive neurons innervating the disc to stimuli that...

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Bibliographic Details
Main Authors: Joshua D. Stover, Matthew A. Trone, Brandon Lawrence, Robby D. Bowles
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:JOR Spine
Subjects:
back pain
discogenic pain
inflammation
mechanical nociception
Online Access:https://doi.org/10.1002/jsp2.1253

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